Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also …

2024年12月24日 · CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcoholic Liver Cirrhosis and Alcohol …

CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol …

CYP2E1 has the highest catalytic activity among the members of cytochrome P450 enzymes in metabolizing alcohol (ethanol). The role of CYP2E1 becomes particularly important when …

2020年5月1日 · That role is shared with two other enzymes that oxidize ethanol, alcohol dehydrogenase and catalase. P450 2E1 is also involved in the bioactivation of a number of …

Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for metabolizing a number of …

The cDNA of human CYP2E1 can be successfully cloned, and a cell line, HepG2-CYP2E1 can efficiently express mRNA and has CYP2E1 activity. This study shown that the genotypes of …

CYP2E1 is located within the placental trophoblast, and has been detected in this tissue during all three trimesters (Hakkola et al. 1996). CYP2E1 is most notably involved in the bioactivation of …

2001年12月25日 · Hepatic CYP2E1 content significantly correlated with the maximal 6-hydroxychlorzoxazone concentration (r=0·76, P < 0·001) and other pharmacokinetic …

2025年2月8日 · Title: Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes. DNA methylation and histone acetylation …