CXCR3 is present in tumor and immune cells, and its two variants, CXCR3-A and CXCR3-B, have different molecular characteristics and can mediate biological effects with opposite results. Blocking CXCR3-A in tumor cells may be a novel anti-tumor strategy to prevent tumor cell invasion and metastasis.

2011年3月10日 · CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4(+) T cells and effector CD8(+) T cells. …

2024年12月24日 · CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis . Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling .

2022年1月18日 · CXCR3 is a chemokine receptor expressed by populations of antigen-experienced CD8+ T cells, including T MEM and T INT cells, and has been implicated in driving T cells into the splenic red pulp and toward an effector fate in settings of early acute infection and vaccination (Hu et al., 2011; Kohlmeier et al., 2011; Kurachi et al., 2011; Shah et ...

2023年6月30日 · Here, Moreno Ayala et al. show that CXCR3 expression on Treg cells puts them in close proximity to CXCL9-producing dendritic cells in tumors, where they suppress tumor antigen presentation and impede the antitumor CD8+ T cell response.

CXCR3 (GPR9/CD183) is an interferon-inducible chemokine receptor expressed on various cell types, but preferentially monocytes, Th1 T cells, CD8 T cells, NKT cells, NK cells, dendritic cells, and some cancer cells (19–21). Homeostatic proliferation of T cells in immune depleted individuals can also lead to an enrichment of CXCR3 + T cells ...

By reviewing the current evidence, we discussed the possible involvement of CXCR3 in neurological diseases. These studies provided hard evidence that CXCR3 plays a vital role in the pathogenesis of MS, glioma, AD, chronic pain, HAM/TSP and bipolar disorder. CXCR3 is a crucial molecule in neuroinflammatory and neurodegenerative diseases.

Human chemokine receptor CXCR3 (CXCR3-B) transduces apoptotic but not chemotactic signals in microvascular endothelial cells following exposure to high concentrations of CXCL4. CXCR3 <-> ligand-mediated lymphocyte recruitment is involved in …

CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation, and preferentially remains highly expressed on type-1 helper (Th1)-type CD4(+) T cells, effector CD8(+) T cells and innate-type lymphocytes, such as natural killer (NK) and NKT cells.

CXCR3 is a G protein-coupled, seven-transmembrane receptor that binds and is activated by the three IFN-gamma-inducible chemokines of the CXC family named CXCL9, CXCL10, and CXCL11. These chemokines are not constitutively expressed but are up-regulated in a proinflammatory cytokine milieu.