2024年12月24日 · CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Cervical Squamous Cell Carcinoma and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling.

2016年1月5日 · CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migration, also executes antimicrobial immunity.

The chemokine CXCL14 is a highly conserved, homeostatic chemokine which is constitutively expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well as impacting epithelial cell motility, CXCL14 contributes to the ...

CXCL14 inhibits colorectal cancer migration, invasion, and epithelial-to-mesenchymal transition (EMT) by suppressing NF-kappaB signaling. Downregulation of CXCL14 expression is associated with gastric adenocarcinoma. CXCL14 plays a pivotal role as a potential tumor suppressor in hepatocellular carcinoma.

As a member of the CXC subfamily of chemokines, CXCL14 is responsible for the infiltration of immune cells, maturation of dendritic cells, upregulation of major histocompatibility complex (MHC)-I expression, and cell mobilization.

A recent study indicated that CXCL14 regulates the development of the microglia in the early cortex, and it is important for cell localization in early cortical stages . CXCL14 is expressed in GABAergic interneurons of the adult mouse dentate gyrus and inhibits GABAergic transmission to neural stem cells [6,7].

The expression of Cxcl14 was positively associated with the onset and severity of cardiac dysfunction in CCI patients. In the CLP mouse model, Cxcl14 aggravated myocardial injury and fibrosis, while promoting the infiltration of inflammatory cells into myocardial tissue.

2024年1月6日 · Patients with idiopathic pulmonary fibrosis show a strongly upregulated expression of chemokine CXCL14, whose target is still unknown. Screening of CXCL14 in a panel of human G protein-coupled...

2025年1月13日 · CXCL14, a chemokine in prostate cancer, displays dual tumor-promoting and -suppressing roles. Key Findings: CXCL14 exhibits variable expression in prostate cancer, influencing tumor microenvironment interactions. Recruitment of immune cells by CXCL14 shapes tumor behavior.

2016年1月5日 · CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migration, also executes antimicrobial immunity.