Coxsackie B is a group of six serotypes of coxsackievirus (CVB1-CVB6), a pathogenic enterovirus, that trigger illnesses ranging from a mild febrile rash to full-fledged pericarditis and myocarditis (coxsackievirus-induced cardiomyopathy). [1][2] The genome of Coxsackie B virus consists of approximately 7,400 base pairs. [3]

Viruses such as coxsackievirus B3 (CVB3) are entirely host cell-dependent parasites. Indeed, they must cleverly exploit various compartments of host cells to complete their life cycle, and consequently launch disease.

Coxsackievirus B3 (CVB3) is a promising novel candidate with particularly valuable features. Its entry receptor, the coxsackievirus and adenovirus receptor (CAR), and heparan sulfate, which is used for cellular entry by some CVB3 variants, are highly expressed on various cancer types.

Coxsackievirus B3 (CVB3) is a principal causative agent of viral myocarditis, meningitis and pancreatitis. There is no vaccine available for clinical use. It has been demonstrated that the primary molecular determinant of virulence phenotype is located in …

2023年1月12日 · In our study, we found that exosomes were prevalent and robust vehicles for the delivery of CVB3 virions, resulting in effective infection of host cells. Additional data confirmed that delivery of CVB3 virions attached to exosomes surmounted barriers to viral tropism.

2003年1月1日 · Coxsackievirus B3 (CVB3) infection can result in myocarditis, which in turn may lead to a protracted immune response and subsequent dilated cardiomyopathy.

2022年4月18日 · Coxsackievirus B3 (CVB3) has emerged as an active pathogen in myocarditis, aseptic meningitis, hand, foot, and mouth disease (HFMD), and pancreatitis, and is a heavy burden on public health. However, CVB3 has not been systematically analyzed with regard to whole-genome diversity and recombination.

2021年6月14日 · In this report, we describe the creation and characterization of an avirulent strain of CVB3 as a live attenuated vaccine to prevent both myocarditis and pancreatitis induced by the wt CVB3...

CVB3-induced myocarditis can be classified into three stages according to its pathogenesis: viral myocarditis, autoimmune myocarditis, and DCM. During the viral myocarditis stage, CVB3 enters into myocytes and activates the host’s innate immunity, which is usually self-limiting.

2024年9月30日 · On the other hand, host cells contain antiviral strategies to restrict CVB replication. The present study aims to address the role played by a cellular protein termed TRIM56 in the infection of CVB3, a representative serotype of CVB, which is the causative agent of inflammatory heart disease.