Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

2017年3月10日 · Here, we show crystal structures of CRM1 bound to eight additional NESs which reveal diverse conformations that range from loop-like to all-helix, which occupy different extents of the invariant NES-binding groove.

2017年6月27日 · Chromosome Region Maintenance1 (CRM1), a nuclear transporter protein, mediates the export of around 220 proteins and mRNA across the nuclear envelope (NE), and is involved in regulation of processes involved with proliferation including cell cycle progression and apoptosis (Xu et al., 2012).

2015年12月17日 · CRM1, also called exportin 1 or Xpo1, is the most conserved nuclear export receptor (Adachi and Yanagida, 1989; Fornerod et al., 1997a; Fukuda et al., 1997; Stade et al., 1997).

2014年1月1日 · CRM1, chromosome region maintenance 1 protein also known as exportin-1 (XPO1), mediates the export out of the nucleus of cellular proteins with a leucine-rich nuclear export signal (NES, a short 8–15 amino acid hydrophobic motif), such as the HIV-1 Rev and the HTLV-1 Rex proteins, and the transport of small RNA cargoes. The gene for CRM1 is ...

2015年9月8日 · Yet, proteins and other molecules can move in and out of the nucleus by passing through small pores in this nuclear membrane. To travel through these pores, larger molecules such as proteins rely on the assistance of transport receptors, including one called CRM1.

CRM1 (Chromosome region maintenance 1; Exportin 1; XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear protein export receptor that recognizes hydrophobic, leucine-rich nuclear export signal (NES) and transports target proteins across a Ran-GTP gradient.

2024年12月10日 · CRM1 (XPO1) has been well-characterized as a shuttling receptor that mediates the export of protein and RNA cargos to the cytoplasm, and previous analyses have pinpointed several key residues (A541, F572, K568, S1055, and …

2014年12月15日 · The location of real NESs near protein termini and within loops or disordered regions may increase their accessibility to CRM1 or enhance their adaptability for suitable CRM1-binding conformations. LocNES outperforms existing NES predictors in Class 3 NES prediction.

CRM1 inhibitors belong to a class of compounds designed to target Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1, a critical mediator of nuclear export. CRM1 plays a fundamental role in nucleocytoplasmic transport by facilitating the export of numerous proteins and RNA molecules from the nucleus to the cytoplasm.