What is Charcot-Marie-Tooth disease type 2 (CMT2)? CMT type 2 (CMT2) is a subtype of CMT that is similar to CMT1 but is less common. CMT2 is typically inherited in an autosomal …

CMT2 patients show little if any slowing in their nerve conductions, and biopsies show the loss of myelinated axons but little segmental demyelination/remyelination. The clinical presentation is …

CMT2 degenerates axons communicating to muscles and conveying information about sensation. CMT2 is a slow, progressive disorder. Over time, muscle weakness and numbness will extend …

2024年6月22日 · CMT2: CMT2 represents 15% to 30% of cases and is characterized by axonal pathology, an autosomal dominant mode of inheritance, onset typically in the second or third …

2021年11月19日 · Charcot-Marie-Tooth disease type 2 (CMT2) is a type of CMT whose genetic defects, or mutations, disrupt the structure and function of axons — the long projections of …

2025年1月6日 · CMT2 affects the axon of peripheral nerve cells and is less common than CMT1. There are more than a dozen types of CMT2, linked to specific gene changes. In addition to …

2023年3月8日 · Charcot-Marie-Tooth disease is an inherited, genetic condition. It occurs when there are mutations in the genes that affect the nerves in your feet, legs, hands and arms.