Cadherin-5, or VE-cadherin (vascular endothelial cadherin), also known as CD144 (C luster of D ifferentiation 144), is a type of cadherin. It is encoded by the human gene CDH5. [5]

2024年12月24日 · CDH5 (Cadherin 5) is a Protein Coding gene. Diseases associated with CDH5 include Periapical Granuloma and Epithelioid Sarcoma. Among its related pathways are Cell junction organization and Blood-Brain Barrier and Immune Cell …

Cadherin 5 (CDH5) functions critically in maintaining cell adhesion and integrity of endothelial and vascular cells. The expression of CDH5 is abnormal in tumor cells, which may have great potential to serve as a new immune checkpoint. The current ...

2025年2月8日 · Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance.

2014年10月23日 · Sauteur et al. have investigated the cell dynamics that occur during angiogenic stalk elongation. They show that endothelial cell elongation is driven by a transformation of junctional contacts from round to elliptic and that this transformation requires the adhesion molecule Cdh5 as well as actin polymerization.

2023年9月21日 · The expression of CDH5 is abnormal in tumor cells, which may have great potential to serve as a new immune checkpoint. The current pan-cancer analysis was performed to better understand the role of CDH5 in tumor.

This study demonstrated that changes in gene expression of CDH5 and CLDN5 due to shear stress within individual differentiations also revealed no trend. Data suggest that cadherin 5 (CDH5) may play a key role in hematogenous recurrence of advanced gastric cancer and may be a viable treatment target.

2025年1月4日 · Clinical resource with information about CDH5, Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH)., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2021年12月21日 · Background: Expressed by endothelial cells, CDH5 is a cadherin involved in vascular morphogenesis and in the maintenance of vascular integrity and lymphatic function. The main purpose of our study was to identify distinct variants of the CDH5 gene that could be associated with lymphatic malformations and predisposition for lymphedema.

2023年12月1日 · Vascular endothelial cadherin (VE-cadherin), also known as cadherin 5 (CDH5), plays a crucial role in endothelial adherens junction assembly and maintenance, thus controlling the integrity and permeability of vessels [6].