Cadherin-5, or VE-cadherin (vascular endothelial cadherin), also known as CD144 (C luster of D ifferentiation 144), is a type of cadherin. It is encoded by the human gene CDH5. [5]

2024年12月24日 · CDH5 (Cadherin 5) is a Protein Coding gene. Diseases associated with CDH5 include Periapical Granuloma and Epithelioid Sarcoma. Among its related pathways are Cell junction organization and Blood-Brain Barrier and Immune Cell …

Shen等人研究发现颗粒酶B（GzmB）裂解重组CDH5（VE-Cadherin）蛋白（购自义翘神州，货号：50192-M08H）导致内皮屏障功能破坏和血管通透性增加，影响心脏纤维化发展。

VE-cadherin (CDH5)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白特性，蛋白表达，蛋白定位及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助您实验成功。

2014年10月23日 · Sauteur et al. have investigated the cell dynamics that occur during angiogenic stalk elongation. They show that endothelial cell elongation is driven by a transformation of junctional contacts from round to elliptic and that this transformation requires the adhesion molecule Cdh5 as well as actin polymerization.

Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance.

2025年2月8日 · Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance.

Serum CDH5 correlates to poorer survival in patient with hormone-refractory metastatic breast cancer. Lateral accumulation of cadherin fingers in follower cells precedes turning, and increased actomyosin contractility can initiate cadherin finger extension as well as engulfment by a neighbouring cell, to promote follower behaviour.

CDH5，即血管内皮钙粘蛋白，别名VE-cadherin/Cadherin-5。它是一种由CDH5基因编码的II型经典钙粘蛋白家族成员，主要在血管内皮细胞中表达。CDH5的作用机制涉及介导内皮细胞间的同质性粘附，通过其细胞外结构域与相邻细胞的CDH5分子相互作用，形成稳定的粘附连接。

钙粘蛋白 (cadherin，CDH)5，又称血管内皮细胞CDH (vascular endothelial cell-CDH，VE-CDH)，是一种内皮细胞特异性膜蛋白。 CDH5可促进微血管生成，为肿瘤细胞提供适合的支持微环境，并能促进肿瘤细胞增殖和转移。 CDH5与恶性肿瘤发生、发展的各个过程都有密切关系。 文章总结了CDH5在多种肿瘤中的研究现状，评估CDH5在促进肿瘤细胞生成、转移及预后的潜力。 引用本文: 张星海, 方天逸, 边秀兰, 等. CDH5在恶性肿瘤中的研究进展 [J] . 国际免疫学杂志, …