CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. [3][4][5] The protein has a mass of 32 kD.

CD99 is a cell surface protein with unique features and only partly defined mechanisms of action. This molecule is involved in crucial biological processes, including cell adhesion, migration, death, differentiation and diapedesis, and it influences ...

2024年12月24日 · CD99 (CD99 Molecule (Xg Blood Group)) is a Protein Coding gene. Diseases associated with CD99 include Extraosseous Ewing Sarcoma and Lymphoblastic Lymphoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD99L2.

This review summarizes the recent progress of CD99 in cancer research and targeting therapies, especially in cancer immunotherapy, which may help researchers understand the crucial roles of CD99 in cancer development and design new therapeutic strategies.

CD99 in humans is a 32 kD highly O-glycosylated cell surface protein expressed on most leukocytes. We recently found CD99 to be expressed in leukocytes and at human endothelial cell contacts.

2019年4月2日 · CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is highly expressed by these tumors. It has been reported that CD99 can affect the migration, invasion and metastasis of tumor cells. Our results show that CD99 is also highly expressed in the tumor vasculature of most solid tumors.

2023年8月23日 · CD99 is expressed in specific cell states of gliomas. Under hypoxia conditions, CD99 is upregulated and is associated with angiogenesis and metabolic reprogramming. Gliomas with over-expressed CD99 increases the infiltration of tumor-associated macrophages.

2002年1月14日 · CD99 is a heavily O-glycosylated 32-kD type I transmembrane protein that is expressed on most hematopoietic cells. We show here that CD99 is expressed on endothelial cells and is...

2018年1月25日 · CD99, a glycosylated transmembrane protein, is involved in many essential cellular functions. For example, cell adhesion and migration, cell death and differentiation, intracellular protein trafficking, endocytosis and exocytosis are influenced by the CD99-regulated signaling. Figure 1 schematizes the effects of CD99 on biological processes.

2015年10月15日 · CD99 is a commonly available immunostain with various uses. It stains a lot of different tumour and has been described by one soft tissue pathologist as slutty.