CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes tumor progression by suppressing antitumor immune response and promoting angiogenesis.

CD73, mainly by the production of adenosine, is critical in the suppression of an adequate anti-tumour immune response, but also in promoting cancer cell proliferation, tumour growth, …

2024年12月30日 · CD73, an ectoenzyme responsible for adenosine production, is often elevated in immuno-suppressive tumor environments. Inhibition of CD73 activity holds great promise as …

Accumulating data suggest that solid tumors hijack cellular plasticity possibly to evade detection by the immune system. CD73-mediated generation of the purine nucleoside adenosine, is an …

2020年1月24日 · CD73, an ecto-5′-nucleotidase (NT5E), serves as an immune checkpoint by generating adenosine (ADO), which suppresses immune activation through the A 2A receptor. …

2021年10月8日 · Here we report that human effector CD8 T cells contribute to adenosine production by releasing CD73-containing extracellular vesicles upon activation. These …

CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive …

Methods To evaluate the effect of CD73 blockade on IL-2 signaling of CD8 + T cells, we screened novel CD73 antibodies using human single-chain variable fragment phage library and …

2021 年 9 月 17 日，阿斯利康公布了CD73抗体，NKG2A抗体联用PDL1抗体治疗不可切除的III期非小细胞肺癌患者的临床试验结果。 天境生物在2022年5月公布了截止到同年3月29日最新的 …

The CD39 /CD73/A2AR signaling pathway has been shown to be associated with poor cancer prognosis. In addition, CD39 and CD73 are also involved in the formation of new lymphatic …