2024年12月24日 · CD63 (CD63 Molecule) is a Protein Coding gene. Diseases associated with CD63 include Fundus Albipunctatus and Congenital Stationary Night Blindness . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System .

CD63 is a ubiquitously expressed protein that is localized within the endosomal system and at the cell surface (Fig. 1). In most cells the major pool of CD63 resides in late endosomes/MVBs and lysosomes, which is why it is also referred to as a lysosomal membrane protein.

4 天之前 · CD63 pathway from host multivesicular bodies provides essential lipids to Chlamydia to maintain productive intracellular infection (J Cell Sci 2006;119:350)

2024年6月17日 · Here we report that a key component of small extracellular vesicles, the tetraspanin CD63, sorts cholesterol to ILVs, generating a pool that can be mobilized by the NPC1/2 complex, and exported...

2021年8月6日 · In this study, we identify tetraspanin CD63 as a novel functional marker of HSCs in mice. We show that CD63 is unevenly expressed on the cell surface in HSC populations.

This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and β1-integrin, the roles of the TIMP-1/CD63/β1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly.

2024年6月21日 · CD63 contributes to tumor progression through its interactions with TIMP-1, whereby it activates signaling pathways that improve cell proliferation, survival, and migration.

2009年5月15日 · The complex localization pattern of CD63 suggests that its intracellular trafficking and distribution must be tightly regulated. In this review we discuss the latest insights in CD63 trafficking and its emerging function as a transport regulator of its interaction partners.

Overall, CD63 promotes the efficient production and release of infectious HBV particles, and its suppression induces secretion of subviral particles and viral particles that are less infective. CD63 belongs to the tetraspanin family and is mostly present in …

5 天之前 · Under certain stimuli, CD63 relocates to the plasma membrane, where it contributes to cell adhesion and membrane trafficking. The abundance of CD63 on exosomes varies by cell type and physiological state. Some cells, such as melanocytes and platelets, exhibit high levels of CD63 due to its role in vesicular transport and secretion.