Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. [5] DAF regulates the complement system on the cell surface. It recognizes C4b and C3b fragments that are created during activation of C4 (classical or lectin pathway) or C3 (alternative pathway).

CD55 deficiency, also called DAF deficiency or CHAPLE syndrome, is a rare genetic disorder of the immune system. CHAPLE stands for "CD55 deficiency with hyper-activation of complement, angiopathic thrombosis, and severe protein-losing enteropathy (PLE)."

2024年12月24日 · CD55 (CD55 Molecule (Cromer Blood Group)) is a Protein Coding gene. Diseases associated with CD55 include Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy and Blood Group, Cromer System .

2023年11月29日 · CD55 deficiency, also known as complement system hyperactivation, angiopathic thrombosis, and early-onset protein-losing enteropathy (CHAPLE) syndrome, is caused by biallelic loss-of-function mutations in the gene encoding complement inhibitor CD55 (decay-accelerating factor). 1 As a glycosylphosphatidylinositol-anchored membrane protein, …

The major isoform of DAF, or CD55, is a 70-kD plasma membrane protein that is widely distributed on all blood cells and on endothelial and epithelial tissues. The physiologic role of DAF is to inhibit the complement cascade at the level of the critical C3 (120700) convertase step.

CD55 is expressed on cells to protect them from complement attack. It is therefore present on all cells that are exposed to complement including red blood cells, leukocytes, endothelial...

2017年12月7日 · CD55 (OMIM*125240; also known as Decay-Accelerating Factor for complement or DAF) is a plasma membrane protein that is widely distributed on all blood cells and many other cell types. A critical physiologic role of CD55 is to inhibit the complement cascade at the level of the central C3 convertase step.

2023年8月18日 · FDA has approved Veopoz (pozelimab-bbfg) injection, a complement inhibitor, for the treatment of adult and pediatric patients 1 year of age and older with CD55-deficient protein-losing...

Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants.

CD55, also known as decay-accelerating factor (DAF), is a membrane protein that plays a crucial role in regulating the complement system by preventing the formation of the C3 convertase enzyme complex.