CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated …

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here we discuss the expression, structure, and …

CD28 is a glycoprotein that is constitutively expressed on both resting and activated T cells. It plays a crucial role in T cell activation and signaling, promoting cell cycle entry and the …

2024年12月24日 · CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Immunodeficiency 123 With Hpv-Related Verrucosis and Classic Mycosis …

CD28 family receptors are a group of regulatory cell surface receptors expressed on immune cells. The CD28 family in turn is a subgroup of the immunoglobulin superfamily.

Here, we discuss recent insights into the molecular events underlying CD28-mediated co-stimulation, its impact on gene regulation, and the differential role of CD28 expression on Treg …

2024年7月25日 · We describe how CD28 is central to the success of current cancer immunotherapies and examine how new questions arising from studies of CD28 as a clinical …

In this paper, we mainly introduce the structure of CD28 and its related biological functions, as well as the application of costimulatory pathways targeting CD28 in disease treatment.

2001年12月1日 · CD28 crosslinking reduces the number of TCRs that need to be engaged, as well as the time required for T cells to interact with antigen, and enhances the magnitude of …

2017年3月9日 · However, Hui et al. find instead that the TCR costimulatory receptor, CD28, is the primary target of PD-1 signaling. Independently, Kamphorst et al. show that CD28 is required …