
CD28 - Wikipedia
CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6.
CD28 costimulation: from mechanism to therapy - PMC
Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here we discuss the expression, structure, and biochemistry of CD28 and its ligands. CD28 signals play a ...
CD28 - an overview | ScienceDirect Topics
CD28 is a glycoprotein that is constitutively expressed on both resting and activated T cells. It plays a crucial role in T cell activation and signaling, promoting cell cycle entry and the production of various cytokines and chemokines. CD28 also induces the expression of other costimulatory and regulatory molecules.
CD28 Gene - GeneCards | CD28 Protein | CD28 Antibody
2024年12月24日 · CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Immunodeficiency 123 With Hpv-Related Verrucosis and Classic Mycosis Fungoides. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer.
CD28 family receptor - Wikipedia
CD28 family receptors are a group of regulatory cell surface receptors expressed on immune cells. The CD28 family in turn is a subgroup of the immunoglobulin superfamily.
CD28 co-stimulation in T-cell homeostasis: a recent perspective
Here, we discuss recent insights into the molecular events underlying CD28-mediated co-stimulation, its impact on gene regulation, and the differential role of CD28 expression on Treg cells versus conventional CD4 + and CD8 + T-cells.
CD28 co-stimulation: novel insights and applications in cancer
2024年7月25日 · We describe how CD28 is central to the success of current cancer immunotherapies and examine how new questions arising from studies of CD28 as a clinical target have enhanced our understanding...
CD28: A New Drug Target for Immune Disease - PubMed
In this paper, we mainly introduce the structure of CD28 and its related biological functions, as well as the application of costimulatory pathways targeting CD28 in disease treatment.
T-cell regulation by CD28 and CTLA-4 - Nature
2001年12月1日 · CD28 crosslinking reduces the number of TCRs that need to be engaged, as well as the time required for T cells to interact with antigen, and enhances the magnitude of the T-cell response.
T cell costimulatory receptor CD28 is a primary target for PD-1 ...
2017年3月9日 · However, Hui et al. find instead that the TCR costimulatory receptor, CD28, is the primary target of PD-1 signaling. Independently, Kamphorst et al. show that CD28 is required for PD-1 therapies to kill cancer cells efficiently and eliminate chronic viral infections in mice.