This review summarizes recent data on CD23, a low affinity receptor for IgE (Fc epsilon RII). CD23 is the only FcR which does not belong to the immunoglobulin gene superfamily.

The lower-affinity IgE Fc receptor, CD23, has multiple functions in enhancing the ... The association of immunoglobulin E (IgE) with allergic diseases and asthma is well established. IgE binds to two receptors on various immune and inflammatory cells.

While evidence from experimental disease models as well as allergic patient studies on CD23 is still lacking, evidence shows that i) CD23 can absorb and clear IgE from the serum in a non‐inflammatory fashion, ii) CD23 reduces the synthesis of IgE from B cells, iii) CD23 regulates antigen‐specific IgG and T cell responses.

2016年5月16日 · We examined the expression of CD23 in different subsets of peripheral B cells and the impact of CD23 expression on the early events of B-cell receptor (BCR) activation using CD23 knockout...

39.5.2.2 CD23 (FcεRII): The Low-affinity Receptor for IgE. CD23 is a type II integral membrane protein with an extracellular C-terminal domain that is homologous to C-type lectins.

CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities.

The low affinity IgE receptor, Fc∊RII (CD23), is both a positive and negative regulator of IgE synthesis. The proteinase activity that converts the membrane-bound form of CD23 into a soluble species (sCD23) is an important regulator of the function ...

CD23 is an IL-4–inducible cell-surface protein that, in both its surface and soluble forms, has been implicated in a variety of biologic responses, including IgE production and T H 2 and dendritic cell function. The anti-CD23–primatized IgG1 antibody consists of cynomolgous macaque variable regions and human constant regions.

CD23, also known as the low affinity receptor for IgE (FcεRII), belongs to a novel superfamily of type-II integral membrane proteins.

2014年12月6日 · The CD23 protein can be cleaved and released into the serum as a soluble form of CD23 (sCD23). The sCD23 is a 25kDa fragment that can be found in serum, plasma and urine in patients with chronic lymphocytic leukemia.