CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 …

2025年1月9日 · CD11c dendritic cells encompass a variety of subtypes, each with distinct origins, phenotypes, and roles in the immune system. These subtypes contribute to a nuanced …

It can be employed to determine the subsets of dendritic cells (DC) in the immune system (see CD11c expression in human and murine immune system), but CD11c may be more than a …

The leukocyte integrin CD11c is a myeloid marker expressed on most DCs (Table 1). CD11c + DCs can be further subdivided by their expression of CD8α, the alpha chain of the T-cell co …

Furthermore, CD11c + CD11b + DCs, but not CD11c + CD8α + DCs, inhibited MOG-induced proliferative responses in a dose-dependent manner, and IL-10 was involved in the process. …

2018年6月26日 · CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, …

The CD11c marker is a protein found on the surface of certain immune cells, including macrophages, a type of white blood cell that engulfs and digests cellular debris and foreign …

2021年3月12日 · Circulating CD11c + B cells are a key phenomenon in certain types of autoimmunity but have also been described in the context of regular immune responses (i.e., …

CD11c+ cells increase greatly with islet inflammation in non-obese diabetic mice and contribute to autoimmune destruction of pancreatic beta cells. In this study, we investigated their origin and …

CD11c + T-bet + atypical B cells (ABCs) have been identified in the context of vaccination, acute and chronic infections and autoimmune disease. However, the origins and functions of ABCs …