2025年2月11日 · CD11b is a critical marker in immunology, primarily associated with myeloid cells. Its significance extends beyond basic research, influencing our understanding of immune responses and disease processes. By examining CD11b’s roles, we gain insight into its importance in both normal physiological functions and pathological conditions.

Integrin αM (CD11b) is expressed in myeloid-lineage cells such as monocytes/macrophages, neutrophils, eosinophils, and basophils, and in lymphoid cells such as NK cells and peritoneal B-1 cells (Springer, 1994). Mac-1 binds multiple ligands, including ICAM-1 (CD54), ICAM-2 …

CD11b is an integrin family member which pairs with CD18 to form the CR3 heterodimer. CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on …

CD11b is a protein on immune cells like macrophages and microglia, aiding in cell adhesion, migration, and immune response. It’s used in immune and neuro research.

2015年4月22日 · Learn about CD11 and its role in adhesion-related association between cell and as a marker for macrophages and microglia, plus functional studies using CD11b antibodies.

2018年12月19日 · Here we report that, unexpectedly, integrin CD11b does not regulate myeloid cell recruitment to tumors but instead controls myeloid cell polarization and tumor growth. CD11b activation promotes...

2004年11月16日 · The findings show that CD11b is expressed on chronic B cell lymphoproliferative disorders. In particular, it is expressed on almost all CLL cases that contain large cells or prolymphocytes and on PLL.

1992年8月15日 · We have found that CD11b, a cell surface integrin of macrophages, granulocytes, and NK cells, is expressed by a subset of CD8+ T cells that include both the active virus-specific CTL and the virus-specific memory CTL populations.

In a recent issue of The Journal of Experimental Medicine, Griffin and Rothstein described two subsets within the human B1 cell compartment: a major CD11b − subset (9/10th of the population) and a minor CD11b + subset (1/10th of the population), with the latter being increased in lupus (Griffin and Rothstein, 2011).

2018年12月19日 · Here we report that, unexpectedly, integrin CD11b does not regulate myeloid cell recruitment to tumors but instead controls myeloid cell polarization and tumor growth. CD11b activation promotes pro-inflammatory macrophage polarization by stimulating expression of microRNA Let7a.