2024年12月24日 · CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Polycystic Lung Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Class A/1 (Rhodopsin …

Macrophages play a critical role in the establishment of a regulated inflammatory response following tissue injury. Following injury, CCR2 + monocytes are recruited from peripheral blood to wound tissue, and direct the initiation and resolution of …

2023年1月31日 · C-C chemokine receptor 2 (CCR2) is a dual-function receptor. Similar to other G protein–coupled chemokine receptors, it promotes monocyte infiltration into tissues in response to the chemokine CCL2...

The CCL2-CCR2 axis is currently the most well-studied chemokine pathway in liver disease. CCR2 and its ligands have become therapeutic targets of interest for biopharmaceutical companies. Among them, CVC is an orally active, dual antagonist of CCR2 and CCR5 .

CCR2 refers to a receptor that plays a crucial role in attracting monocytes and macrophages in the context of COPD. Blocking CCR2 has the potential to be a therapeutic strategy for this condition. You might find these chapters and articles relevant to this topic.

2023年9月1日 · C–C motif chemokine receptor 2 (CCR2), together with its ligands, especially C–C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in …

2016年12月7日 · CC chemokine receptor 2 (CCR2) is one of 19 members of the chemokine receptor subfamily of human class A G-protein-coupled receptors. CCR2 is expressed on monocytes, immature dendritic...

2025年2月8日 · Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.

Reverse phase protein array analysis revealed that cell cycle protein expression was associated with CCR2 expression in basal-like breast cancer cells. CCL2 treatment of basal-like breast cancer cell lines increased proliferation and cell cycle progression associated with …

2022年5月12日 · C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell migration toward MCP-1 in inflammation-related diseases. The CCR2 gene encodes two isoforms: CCR2A and CCR2B.