2024年12月24日 · CCND1 (Cyclin D1) is a Protein Coding gene. Diseases associated with CCND1 include Myeloma, Multiple and Von Hippel-Lindau Syndrome. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, E2F3) and Regulation of activated PAK-2p34 by proteasome mediated degradation.

2025年2月9日 · CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma. Mohanty A, et al. Oncotarget, 2016 Nov 8. PMID 27713153, Free PMC Article. Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma. Lin L, et al. Mod Pathol, 2005 May. PMID 15578074.

CCND1 is a predictive biomarker for use of ibrutinib in patients. Mantle cell lymphoma and mature B-cell lymphoma/leukemia have the most therapies with CCND1 as a predictive biomarker.

Cyclin D1 is a 36-kDa protein encoded by CCND1 gene, located on chromosome 11q13. Cyclin D1 is expressed by the majority of normal human cells apart from cells derived from bone marrow stem cell lines [8].

2016年5月16日 · Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1·Cdk4 expression promotes tumour...

2025年1月5日 · Clinical resource with information about CCND1, A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age., Colorectal cancer, Genetic variants associated with breast size also influence breast cancer risk., Genome-wide ...

2025年2月9日 · Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53. MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1. Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma.

2020年8月10日 · Cyclin D1 (CCND1) amplification relevant to malignant biological behavior exists in solid tumors. The prevalence and utility of CCND1 amplification as a biomarker for the clinical response to treatment with immune checkpoint inhibitors (ICIs) are unknown.

Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (PubMed:9106657). Interacts directly with CDKN1B (By similarity). Can form similar complexes with either CDKN1A or CDKN2A (By similarity).

CCND1 is the regulatory subunit of a holoenzyme that phosphorylates and inactivates the RB protein (RB1; 614041) and promotes progression through the G1-S phase of the cell cycle in a manner dependent on cyclin-dependent kinases, or CDKs (see CDK2; 116953). In addition, CCND1 has a number of cell cycle- and CDK-independent functions.