This, in turn, results in the production of additional inflammatory cytokines, thereby amplifying the inflammatory response within the intestinal tract. 14–16 Furthermore, chemokines released by monocytes, such as CCL11, can attract other immune cells, including neutrophils and eosinophils, to sites of inflammation, exacerbating tissue damage wi...

Eotaxin – or CCL11 – is another β-chemokine (CC chemokine) that is apparently involved in the pathogenesis of endometriosis.

CCL11 is a member of the eotaxin family that is chemotactic agents for eosinophils and participate in innate immunity. Eotaxins may exert physiological and pathological functions in the central nerve system, and CCL11 may induce neuronal cytotoxicity effects by inducing the production of reactive oxygen species (ROS) in microglia cells.

Background: CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL-11 plays a role in brain disorders as well. This paper reviews the associations between CCL-11 and aging, neurodegenerative, neuroinflammatory and neuropsychiatric disorders.

Chronic inflammation involves CCL11 and IL-13 to facilitate the development of liver cirrhosis and fibrosis in chronic hepatitis B virus infection. Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for …

2024年12月24日 · CCL11 (C-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include Asthma and Human Immunodeficiency Virus Type 1. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity.

We have reported that CCL11 is significantly increased in the serum of inflammatory bowel disease (IBD) patients, colonic eosinophils are increased and correlate with tissue CCL11 levels in ulcerative colitis patients, and CCL11 is increased in …

2020年9月2日 · Background: CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL-11 plays a role in brain disorders as well. This paper reviews the associations between CCL-11 and aging, neurodegenerative, neuroinflammatory and neuropsychiatric disorders.

2023年10月4日 · Results: Our study revealed that eotaxin-1/CCL11 promote reactive oxygen secretion (ROS) production in lung fibroblasts, accompanied by increased activation of the DNA damage response (DDR) and p-TP53 and γH2AX.

CCL11, also known as Eotaxin-1, is a protein secreted by various cells in the body, such as lymphocytes and monocytes, that plays a role in attracting immune cells and inducing inflammation, potentially contributing to neurological disorders like ASD. You might find these chapters and articles relevant to this topic. Junrui Ye, ... Naihong Chen.

2023年7月1日 · 趋化因子配体11 (CCL11)也称为 嗜酸性粒细胞 趋化因子 (Eotaxin)，是CC趋化因子家族中的小分子量细胞因子 [5]。 大部分与 CCL11 相关的研究都集中在它作为嗜酸性粒细胞转运的调节因子的作用，相比之下，CCL11 的嗜酸性粒细胞非依赖性作用几乎没有得到充分研究。 根据Berkman 等人的一项研究表明，CCL11 可以在体外直接增强人肺成纤维细胞的 ECM 生成 …

2021年10月8日 · We have reported that CCL11 is significantly increased in the serum of inflammatory bowel disease (IBD) patients, colonic eosinophils are increased and correlate with tissue CCL11 levels in...

2017年7月13日 · In chronic inflammatory disease with disturbed bone remodelling, e.g. rheumatoid arthritis, patients show increased serum levels of the chemokine eotaxin-1 (CCL11). Herein, we demonstrate an...

Our data suggest that CCL11 is a novel regulator of NAFLD and can be effectively targeted for NAFLD intervention. Non-alcoholic fatty liver disease (NAFLD) precedes cirrhosis and hepatocellular carcinoma. In this paper we describe the regulatory role of CCL11, a C–C motif ligand chemokine, in NAFLD pathogenesis.

CCL11 blockade reduced the proportion of CD4+CD25+Foxp3+ Treg cells, the expression of CCR3 and Foxp3, and the level of STAT5 activation in tumor‑associated CD4+ T cells, in a dose‑dependent manner.

In addition to its role in immune response, recent studies have shown that eotaxin-1/CCL11 is associated with aging, neurogenesis and neurodegeneration, being able to influence neural progenitor cells, and microglia.

2024年2月4日 · CCL11, a chemokine known for recruiting immune cells to the tumor microenvironment (TME), has an unclear role in the context of its expression, patient prognosis, and the presence of tumor-infiltrating immune cells (TILs) in breast cancer. The expression of CCL11 in invasive breast cancer (BRCA) was analyzed using TCGA database.

Conclusions: CCL11 is a potentially useful biomarker for the diagnosis and assessment of asthma severity and control, especially in sputum. CCL11 is crucial in eosinophil chemoattraction and activation in asthma pathogenesis.

2024年2月2日 · In vitro experiments substantiated CCL11's anticancer effects in BRCA. CCL11 expression correlates with immune cell infiltration in breast cancer, indicating its potential as a prognostic biomarker for BRCA. Breast cancer represents the most prevalent malignancy among women globally.