CCL1 is expressed by T cells, mast cells, and, in response to LPS or inflammatory cytokines, by monocytes and macrophages. CCL1 signals through CCR8, the only chemokine to do so. CCR8 is expressed on thymocytes, on monocytes, and, similar to …

2024年12月24日 · CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include Kaposi Sarcoma and Mast-Cell Leukemia. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity.

2011年2月7日 · Volume 1. Andrew Williams, in Encyclopedia of Respiratory Medicine(Second Edition), 2022. CCL1. The gene for CCL1 is located within the CC-chemokine cluster on human chromosome 17 and codes for a protein with a molecular weight of approximately 15–16 kDa (also known as small inducible cytokine A1 or T Lymphocyte-secreted protein I-309, and is …

CCL1 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. These data identify a novel function for CCL1-CCR8 in metastasis and lymph node LECs as a critical checkpoint for the entry of metastases into the lymph nodes. CCL1, CCL26, and IgE may be associated with pruritus in cutaneous T-cell lymphoma.

Liu et al. (2021) found that the expression of CCL1 is upregulated in lung tissues of PF patients and mice. CCL1 exerts its fibrogenic activity by signaling through autocrine motility factor receptor (AMFR) on lung fibroblasts and activating those cells into pathological myofibroblasts.

2011年11月4日 · CCL1 transcription was increased in primary human CD4 + T cells abundantly expressing TIM-3 but not in cells with low expression of TIM-3. CCL1 was identified as a differentially transcribed gene in TIM-3-expressing CD4 + T cells. Keywords: TIM-3, Gene expression, CD4+ T cell, CCL1.

CCL1 is a small glycoprotein belonging to the CC chemokine family with a molecular weight of approximately 15-16 kDa, known as small inducible cytokine I-309 in humans and TCA-3 in mice. CCL1 is secreted by activated monocytes, macrophages, T lymphocytes and endothelial cells and is chemotactic for monocytes but not for neutrophils [1].

2018年12月20日 · We found a high expression of CCL1 in human breast cancer. CCL1 significantly correlated with the infiltration of immunosuppressive FoxP3+ Treg, that are known to negatively affect survival. Thus, CCL1 may serve as prognostic marker and novel therapeutic target in breast cancer.

We found that CCL-1 was upregulated in the spinal dorsal horn after partial sciatic nerve ligation. Therefore, we examined actions of recombinant CCL-1 on behavioural pain score, synaptic transmission, glial cell function and cytokine production in the spinal dorsal horn.

2011年2月7日 · CCL1, Chemokine (C-C motif) ligand 1, which is also known as I-309 or small inducible cytokine A1, is a monocyte chemoattractant protein of the CCL family. You might find these chapters and articles relevant to this topic. Bernhard Homey MD, ... Donald Y.M. Leung MD, PhD, in Journal of Allergy and Clinical Immunology, 2006.