2024年12月24日 · C1QB (Complement C1q B Chain) is a Protein Coding gene. Diseases associated with C1QB include C1q Deficiency 2 and C1q Deficiency 1. Among its related pathways are Complement cascade and Initial triggering of complement. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

C1q is a 460 kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head.

Official gene symbol, which is typically a short form of the gene name, according to HGNC. Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl.

It can be caused by genetic changes in the C1QA, C1QB or C1QC genes and is inherited in an autosomal recessive pattern. C1q deficiency is a rare disorder associated with recurrent skin lesions, chronic infections, systemic lupus erythematosus (SLE) or SLE-like diseases.

2023年4月12日 · HGNC Approved Gene Symbol: C1QB. Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38) : 1:22,653,236-22,661,637 (from NCBI) C1q, the first subcomponent of C1, has a complicated 18-chain structure: 6 A, 6 B, and 6 C chains.

2024年12月2日 · Human C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA, C1QB, and C1QC genes located on chromosome 1.

the three C1q genes (C1QA, C1QB, and C1QC) [1]. C1q is the rst molecule of the classical complement pathway and plays a major role in the innate immune response, and clearance of immune complexes and apoptotic cells [2 –4]. The rst case of C1q deciency was reported in 1978, describing a 10-year-old boy with recurrent skin lesions

2024年11月5日 · C1qbp is a crucial element of cell adhesion and metastasis, 2 and this link between tumor and macrophage can severely limit effective therapy: BMDM following stimulation/polarization with MM lines, but not naïve/unstimulated BMDM, strongly inhibit anti-BCMA CAR T in vitro cytotoxic activity.

RefSeq Summary (NM_001378156): This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains.

2024年11月4日 · To dig out the potential role of complement C1q in the pathogenesis of MPE, we initially compared the expression levels of C1qa, C1qb, and C1qc within nucleated cells between mouse MPE and blood using quantitative polymerase chain reaction (qPCR).