Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.

这项新研究揭示了一种意想不到的新机制：c-Src 可以通过自我磷酸化自主激活自身，并引发癌症。 迄今为止，人们都已知道c-Src癌基因的功能和活性是由另一种称为CSK的蛋白激酶控制的，CSK会使c-Src中的一个关键酪氨酸磷酸化，从而抑制它的活性。 c-Src的自我磷酸化动力学。 图片来自Nature Communications, 2023, doi:10.1038/s41467-023-41890-7。 但是，Plaza-Menacho说，这些作者如今发现，c-Src“还能通过自身磷酸化来自主调节这个关键酪氨酸的磷 …

In this review, we delve into the discovery of c-Src and v-Src, the structure of c-Src, and the molecular mechanisms that activate c-Src. We also focus on the various signaling pathways that c-Src employs to promote oncogenesis and resistance to chemotherapy drugs as well as molecularly targeted agents.

2000年11月20日 · This review discusses the data supporting a role for c-Src as a critical component of the signal transduction pathways that control cancer cell development and growth, and provides the rationale...

The proto-oncogene c-Src is a non-receptor tyrosine kinase playing a key role in many cellular pathways, including cell survival, migration and proliferation. c-Src de-regulation has been observed in several cancer types, making it an appealing target for drug discovery efforts.

2024年9月29日 · 本研究发现，原癌基因c-SRC在胶质瘤中广泛激活，通过磷酸化激活ACSS2促进乙酸生成乙酰辅酶A，同时磷酸化抑制ACLY使柠檬酸分流至IDH1催化反应，促进NADPH产生。

We found that the N-terminal myristoyl group binds to the SH3 domain (in the so-called RT loop) in free c-Src. This provides an additional stabilizing element to the previously described intramolecular fuzzy complex in which the folded SH3 domain acts as a scaffold for the intrinsically disordered regions.

2019年3月1日 · Our results indicate that activated c-Src in the endosomal membrane promoted the secretion of exosomes, in which c-Src was encapsulated. In addition, the ESCRT-interacting molecule, Alix was...

Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme in pentose phosphate pathway (PPP), excessive activation of which has been considered to be involved in tumorigenesis. Here, we show that tyrosine kinase c-Src interacts with and phosphorylates G6PD at …

2020年6月7日 · The proto-oncogene c-Src is a non-receptor tyrosine kinase playing a key role in many cellular pathways, including cell survival, migration and proliferation. c-Src de-regulation has been observed in several cancer types, making it an appealing target for drug discovery efforts.