Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene. [5] The protein encoded by this gene is a member of the TGF-β superfamily.

bmp7已经成为肾脏发育最关键的bmp之一。 缺乏BMP7的小鼠除了眼睛缺陷外，还有严重的肾脏缺陷。 此外，BMP7信号已被证明对高血压性肾硬化具有保护作用。

2024年12月24日 · BMP7 (Bone Morphogenetic Protein 7) is a Protein Coding gene. Diseases associated with BMP7 include Congenital Heart Defects, Multiple Types, 4 and Ventricular Septal Defect 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

骨形态发生蛋白 7 (BMP-7) 是一种多效性配体蛋白，属于 TGFβ 家族。 BMP-7 参与调节癌细胞的增殖、侵袭和迁移，与多种人类肿瘤相关 [1]。 BMP-7 似乎也表现出对血管的抗炎作用，并可能发挥维持血管完整性的功能 [2]。 BMP-7 可减弱血管钙化，但也可纠正尿毒症相关的高磷血症，并刺激原位磷酸骨化沉积，同时通过直接作用于血管平滑肌细胞防止血管钙化 [3]。 BMP/TGFβ 信号通路参与血管和瓣膜稳态，这是胚胎发育的关键过程 [4]。 由于血清、血小板衍生生长因子亚单 …

2020年1月23日 · Bone morphogenetic protein-7 is (BMP-7) is a potent anti-inflammatory growth factor belonging to the Transforming Growth Factor Beta (TGF-β) superfamily. It plays an important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis.

2025年2月8日 · Bone morphogenetic protein-7 inhibits endothelial-to-mesenchymal transition in primary human umbilical vein endothelial cells and mouse model of systemic sclerosis via Akt/mTOR/p70S6K pathway. BMP7 reduces the fibrocartilage chondrocyte phenotype.

2020年9月24日 · Specifically, we found that anti-PD1-resistant tumors overexpress bone morphogenetic protein (BMP)7, also known as OP-1. BMP7 is a secreted protein that belongs to the transforming growth factor...

The gene encoding bone morphogenetic protein-7 (Bmp7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of Bmp7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BMP7 acts on the nephron progenitor cells to exert its ...

Bone morphogenetic protein 7 (BMP7) is a member of the transforming growth factor-β (TGF-β) superfamily of growth factors. In recent years, it has become clear that BMP7 is a very pleiotropic growth factor.

Bone morphogenetic protein-7 inhibits endothelial-to-mesenchymal transition in primary human umbilical vein endothelial cells and mouse model of systemic sclerosis via Akt/mTOR/p70S6K pathway. Assessment of plasma BMP-2, BMP-7, BMP-10, vitamin D, and TGF β1 in simple fractures among Sudanese patients.