2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and …

2024年12月24日 · BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Cornelia De Lange Syndrome 6 and Cornelia De Lange …

2023年12月22日 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce …

2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and …

BRD4 is a bromodomain and extra terminal (BET) protein that has been described as a protein with many roles. It has been variously defined as a transcription cofactor, chromatin reader …

2022年10月29日 · Results from the drug screening of 464 inhibitors (for 164 targets) applied to ferroptosis cells indicated that 4 inhibitors targeted bromodomain-containing protein 4 (BRD4) …

These findings provide insight into the role of BRD4 in epigenetic regulation of gene pathways that promote the metastatic phenotype of cancer cells and suggest that therapies targeting BRD4 …

2023年5月1日 · BRD4 facilitates the DNA damage response (DDR) by regulating related genes and BRD4 inhibitors can promote cell death by hindering DDR in cancers, including GBM [41].

BRD4 localizes to the promoter-proximal region of genes. At the target gene BRD4 helps to assemble a functional elongation complex at the 5’-end of genes. During this general 5’ …

2021年6月25日 · Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extraterminal (BET) protein family, plays an important role in controlling oncogene expression …