
BRD4 and Cancer: going beyond transcriptional regulation
2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and …
BRD4 Gene - GeneCards | BRD4 Protein | BRD4 Antibody
2024年12月24日 · BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Cornelia De Lange Syndrome 6 and Cornelia De Lange …
Super-enhancers and the super-enhancer reader BRD4 ... - Nature
2023年12月22日 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce …
BRD4 and Cancer: going beyond transcriptional regulation
2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and …
BRD4 and MYC: Power couple in Transcription and Disease
BRD4 is a bromodomain and extra terminal (BET) protein that has been described as a protein with many roles. It has been variously defined as a transcription cofactor, chromatin reader …
Bromodomain-containing protein 4 (BRD4) as an epigenetic
2022年10月29日 · Results from the drug screening of 464 inhibitors (for 164 targets) applied to ferroptosis cells indicated that 4 inhibitors targeted bromodomain-containing protein 4 (BRD4) …
Emerging roles of and therapeutic strategies targeting BRD4 in …
These findings provide insight into the role of BRD4 in epigenetic regulation of gene pathways that promote the metastatic phenotype of cancer cells and suggest that therapies targeting BRD4 …
BRD4: New hope in the battle against glioblastoma
2023年5月1日 · BRD4 facilitates the DNA damage response (DDR) by regulating related genes and BRD4 inhibitors can promote cell death by hindering DDR in cancers, including GBM [41].
BRD4: a general regulator of transcription elongation - PMC
BRD4 localizes to the promoter-proximal region of genes. At the target gene BRD4 helps to assemble a functional elongation complex at the 5’-end of genes. During this general 5’ …
BRD4: An emerging prospective therapeutic target in glioma - Cell …
2021年6月25日 · Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extraterminal (BET) protein family, plays an important role in controlling oncogene expression …
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