
BCL6 Gene - GeneCards | BCL6 Protein | BCL6 Antibody
2024年12月24日 · BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Intravascular Large B-Cell Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Gene expression (Transcription) and Cytokine Signaling in Immune system.
B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral …
2022年12月2日 · B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection, and maintenance of lymphoma cells.
B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity …
B cell lymphoma 6 (BCL6) is a conserved multi-domain protein that functions principally as a transcriptional repressor. This protein regulates many pivotal aspects of immune cell development and function. BCL6 is critical for germinal center (GC) ...
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2023年8月3日 · BCL6 is a transcription factor located at 3q27 and is required for germinal center B cells formation and follicular helper T cells (TFH) differentiation
BCL6 - an overview | ScienceDirect Topics
BCL6 is a transcriptional repressor that plays a role in the development of follicular helper T cells and splenic conventional dendritic cells (cDCs). It is not expressed in early hematopoietic progenitors but is upregulated in the splenic pool of pre-cDCs.
TARGETING BCL-6 IN DIFFUSE LARGE B-CELL LYMPHOMA: WHAT …
BCL6 is required for GC B-cells to proliferate and tolerate the DNA damage that occurs as a byproduct of this process of immunoglobulin affinity maturation [1].
B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral
2022年12月2日 · B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection, and maintenance of lymphoma cells.
B-cell Lymphoma 6 Inhibitors: Current Advances and Prospects of …
B-cell lymphoma 6 (BCL6) is a transcriptional repressor that regulates the differentiation of B lymphocytes and mediates the formation of germinal centers (GCs) by recruiting corepressors through the BTB domain of BCL6.
BCL6: master regulator of the germinal center reaction and key …
BCL6 is a transcriptional repressor which has emerged as a critical regulator of germinal centers (GC), the sites where B cells are selected based on the production of antibodies with high affinity for the antigen.
BCL6 promotes a stem-like CD8 + T cell program in cancer via
2023年10月20日 · Here, we found that BCL6 inhibits tumor-specific T term cell generation from T prog cell downstream of TCF1. We show that Bcl6 deficiency reduced the persistence of T prog cells, without affecting their generation, thus abrogating long-term tumor control.
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