Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene. [5] [6]

2022年8月1日 · What Is the AXIN2 Gene? AXIN2 is a gene that you inherit from your parents. If you develop changes, or mutations, in this gene, it won’t function the way it should. If You Carry an AXIN2 Gene...

2024年12月24日 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

This overview of clinical management guidelines is based on this patient’s positive test result for a pathogenic or likely pathogenic AXIN2 variant. Unless otherwise stated, medical management guidelines used here are limited to those issued by the National Comprehensive Cancer Network® (NCCN®) 1 in the U.S. Please consult the referenced ...

2019年9月18日 · The paralogous scaffold proteins axin and conductin/axin2 are key factors in the negative regulation of the Wnt pathway transcription factor β-catenin, thereby representing interesting targets...

2025年1月4日 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

2025年2月8日 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Uniquely, AXIN2, but not AXIN1, is a transcriptional target of β-catenin-dependent Wnt signaling [34–36], and AXIN2 expression is elevated in cancers with activating Wnt pathway mutations.

The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.