The Argonaute protein family, first discovered for its evolutionarily conserved stem cell function, [1] plays a central role in RNA silencing processes as essential components of the RNA …

Argonaute proteins associate with small non-coding RNAs (such as small interfering (si)RNAs and microRNAs (miRNAs)) and function in RNA-based silencing mechanisms by altering protein …

2013年6月4日 · Argonaute proteins are highly specialized binding modules that accommodate the small RNA component — such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or …

Argonaute RNA is pursuing a number of therapeutic opportunities in RNA interference. RNAi harnesses a cell mechanism that inhibits the expression of a specific gene and thereby inhibits …

2020年7月1日 · Argonaute proteins play an important role in post-translational gene silencing and the biogenesis of small RNA. Accumulating studies have revealed that Argonaute proteins …

MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene expression post-transcriptionally. These non-coding regulatory RNAs become functional after loading into …

2020年1月21日 · Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, …