Stock analysis for Acusphere Inc (AQQ1:GR) including stock price, stock chart, company news, key statistics, fundamentals and company profile.

These two subseries of the AQQs (AQQ1–16) exhibited excellent antimicrobial activity, particularly against S. aureus, E. faecalis, and C. albicans, with low micromolar MIC values compared to that of positive control drugs.

2021年9月1日 · Quinolinequinones (AQQ1-15) were designed and synthesized. The analog (AQQ13) showed good anti-leukemic activity with significant selectivity. AQQ13 underwent DNA cleavage-associated cell death. Molecular docking was carried out to explore the binding of active analog with DNA.

2024年6月3日 · In silico studies (molecular dynamics) with three kinases (CDK2, CDK4, and MAPK) leading to cell cycle arrest at G 0 /G 1 identified MAPK as a probable target for AQQ1. Taken together, our results showed that AQQ1 could be a potential chemotherapeutic lead molecule for prostate cancer.

2024年6月3日 · AQQ1 showed slightly higher cytotoxic activity in DU-145 cells and further investigations are carried out to explore the potential of AQQ1 as cancer treatment option and to understand its mechanism of action better.

Nine previously reported quinolinequinones (AQQ1-9) were studied to better understand their inhibitory profile to produce potent and possibly safe lead molecules.

In the present work, a series of analogs of the LY83583 containing alkoxy group (s) in aminophenyl ring (AQQ1-15) were designed and synthesized via a two-step route and evaluated for their in vitro cytotoxic activity against four different cancer cell lines (K562, Jurkat, MT-2, and HeLa) and human peripheral blood mononuclear cells (PBMCs) by MT...

2024年6月3日 · AQQ1 and AQQ2 were tested for cytotoxicity against the HCT-116 colon cancer, DU-145 prostate cancer, and MDA-MB-231/ATCC breast cancer cell lines in response to the encouraging NCI results. We also decided to find out the effects of the selected quinolinequinone (AQQ1) on prostate

In this study, the aminated quinolinequinones (AQQ1–9) were designed, synthesized, and evaluated for their antimicrobial activity against a panel of seven bacterial strains (three Gram-positive and four Gram-negative bacteria) and three fungal strains. The structure–activity relationship (SAR) for the QQs was also summarized.

In an effort to develop potent and secure antiproliferative lead compounds, five quinolinequinones (AQQ1-5) described previously have been selected and submitted to the National Cancer...