Anaphase-promoting complex - Wikipedia
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large …
所有肿瘤都会发生异常的通路——Cell cycle信号通路（三） - 知乎
APC/C属于环指家族E3泛素连接酶（RING E3）。 与泛素转移过程中形成E3~Ub中间体的HECT E3不同，RING E3缺乏活性位点，不参与泛素转移的化学反应。 取而代之的是， RING E3泛 …
Atomic structure of the APC/C and its mechanism of protein ...
2015年6月15日 · The (APC/C) is a multisubunit E3 ubiquitin ligase enzyme that controls chromosome segregation and the subsequent exit from mitotic cell division.
后期促进复合物 - 百度百科
“后期促进复合物/细胞周期体” (APC/C)是一种大型E3连接酶，介导细胞周期调控蛋白的依赖于泛素的蛋白水解，以在复制和细胞分裂过程中控制各种事件。
APC/C: current understanding and future perspectives - PubMed
2019年5月23日 · The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the …
Molecular architecture and mechanism of the anaphase …
2014年7月20日 · The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins; here the...
APC/C: current understanding and future perspectives - PMC
The APC/C is a multi-subunit cullin-RING E3 ubiquitin ligase. The APC/C belongs to the RING finger family of E3 ubiquitin ligases 22– 26. Unlike the HECT E3s that form E3~Ub …
APC/C ubiquitin ligase: functions and mechanisms in tumorigenesis
We summarize the current state of knowledge regarding APC/C structure and function, as well as the distinct ways Cdh1 and Cdc20 are dysregulated in human cancer. We also discuss APC/C …
The anaphase promoting complex/cyclosome: a machine …
2006年8月9日 · The anaphase promoting complex/cyclosome (APC/C) is a 1.5-MDa ubiquitin ligase complex that initiates sister-chromatid separation and exit from mitosis...
泛素连接酶APC/C参与的泛素化与细胞周期调节
2017年7月5日 · 后期促进复合物/细胞周期体（anaphasepromoting complex/cyclosome，APC/C）是一个多功能的泛素连接酶，参与细胞周期、代谢、DNA损伤 …
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