2024年12月24日 · ANGPT2 (Angiopoietin 2) is a Protein Coding gene. Diseases associated with ANGPT2 include Lymphatic Malformation 10 and Lymphatic Malformation 1. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

Human ANGPT2 genome location and ANGPT2 gene details page in the UCSC Genome Browser.

Angiopoietin-2 (ANGPT2) is an immune target in patients and is involved in resistance to anti-VEGF treatment with the monoclonal antibody bevacizumab. We investigated the predictive and prognostic value of circulating ANGPT2 in metastatic melanoma patients receiving immune checkpoint therapy.

2021年11月11日 · ANGPT2, initially characterized as an antagonistic ligand to ANGPT1, has been shown to be involved in multiple aspects of endothelial biology.

2020年6月12日 · Here, we identify angiopoietin-2 (Angpt2)–integrin α5β1 signaling as an inducer of fat uptake specifically in SAT. Adipocyte-specific deletion of Angpt2 markedly reduced fatty acid uptake and...

3 天之前 · DALLAS – March 17, 2025 – A protein called angiopoietin-2 (ANGPT2) can both inhibit and encourage blood vessel changes critical for sepsis, a leading cause of hospital deaths worldwide, a new study led by UT Southwestern Medical Center researchers shows. Their findings, published in The Journal of Clinical Investigation, provide insight into how those …

2020年6月15日 · Taken together, these findings uncover the hitherto unappreciated role of tumor cell-expressed ANGPT2 as an autocrine-positive regulator of metastatic colonization and validate ANGPT2 as a therapeutic target for a well-defined subset of patients with melanoma.

2025年2月8日 · Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis.

2025年2月8日 · Blood ANGPT2 was significantly higher in chronic hepatitis C patients with liver fibrosis compared to those without fibrosis. This study reveals ANGPT2 as a new susceptibility gene for nAMD and PCV, and it may affect disease susceptibility in association with CFH.

2024年3月1日 · Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis.