AMBRA1 (activating molecule in Beclin1-regulated autophagy) [5] [6] is a protein that is able to regulate cancer cells through autophagy. [7] AMBRA1 is described as a mechanism cells use to divide [ 8 ] and there is new evidence demonstrating the role and impact of AMBRA1 as a candidate for the treatment of several disorders and diseases ...

2024年12月24日 · AMBRA1 (Autophagy And Beclin 1 Regulator 1) is a Protein Coding gene. Diseases associated with AMBRA1 include Liver Carcinoma In Situ and Myopathy, X-Linked, With Excessive Autophagy. Among its related pathways are Alzheimer's disease and miRNA effects and Selective autophagy.

AMBRA1 promotes chemoresistance and survival in breast cancer cells through the AKT-FOXO1-BIM axis. AMBRA1 inhibits tumorigenesis and carcinogenesis by ubiquitylating ALDH1B1, a cancer stem cell marker. AMBRA1 mediates non-proteolytic polyubiquitylation of SMAD4 to enhance its transcriptional functions.

2021年5月14日 · Researchers have shown that the loss of a protein called AMBRA1 can cause tumors to form in mice and is linked with worse outcomes in some human tumors. A lack of AMBRA1 may make some tumors resistant to CDK4/6 inhibitor drugs. The new research may lead to strategies for re-sensitizing cancer cells to these drugs.

The accumulation of abnormal α‐syn can halt the proper function of autophagy. AMBRA1 is a novel α‐syn‐binding protein and is implicated in the pathogenesis of MSA through autophagy. AMBRA1 can have strong potentialities of being both a powerful surveillance protein and an effective degradation protein for abnormal α‐syn. Disclosure

2021年4月14日 · Here we show that autophagy and beclin 1 regulator 1 (AMBRA1) is the main regulator of the degradation of cyclin D. We identified AMBRA1 in a genome-wide screen to investigate the genetic...

2024年2月14日 · The Activating Molecule in Beclin-1-Regulated Autophagy (AMBRA1) is a scaffold protein involved in many cellular processes, including autophagy, apoptosis, cell growth and development.

2025年2月8日 · Ambra1 in exosomes secreted by HK-2 cells damaged by supersaturated oxalate induce mitophagy and autophagy-ferroptosis in normal HK-2 cells to participate in the occurrence of kidney stones. Ambra1 modulates the sensitivity of mantle cell lymphoma to palbociclib by regulating cyclin D1.

The autophagic tumour-suppressor protein AMBRA1 has been linked to the control of cell proliferation, but the underlying molecular mechanisms remain poorly understood. Here we show that AMBRA1 is an upstream master regulator of the transition from G1 to S phase and thereby prevents replication stress.

2022年5月30日 · Therefore, Ambra1 may provide a novel target for cancer treatment, particularly for overcoming anticancer drug resistance. The present review focuses on the role of Ambra1 in autophagy and apoptosis and assesses the implications for cell …

2021年4月14日 · AMBRA1-mediated degradation of cyclin D through CRL4–DDB1 regulates cell proliferation and prevents replication stress in neurodevelopment and cancer.

2023年11月22日 · The HDX results indicated that AMBRA1 is a highly flexible protein and can be stabilized upon interaction with DDB1, the adaptor of the Cullin4A/B E3 ligase. Here, we present the cryo-EM...

2015年6月1日 · The activating molecule in Beclin-1-regulated autophagy (Ambra1), also known as autophagy/Beclin-1 regulator 1, is a highly intrinsically disordered and vertebrate-conserved adapter protein that is part of the autophagy signaling network.

2007年6月24日 · Here we show that Ambra1 (activating molecule in Beclin1-regulated autophagy), a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a...

AMBRA1 is an intrinsically disordered scaffold protein with a unique property of regulating the activity of both proliferation and autophagy core machineries.

Here, we demonstrate that pro-autophagy protein AMBRA1 is also a key modulator of T cells, regulating the complex network that leads to human T reg differentiation and maintenance.

2024年11月7日 · AMBRA1 suppresses Rab40c expression but stimulates Rab40/CRL5 complex formation. AMBRA1 is a well-established substrate receptor of Cullin4 ubiquitin ligase complex, which targets protein ubiquitination and subsequent degradation [15, 20, 34–36].

2017年3月31日 · The experiments show that FAK binds to a protein called Ambra1, which is known to control how other proteins move around inside cells. Ambra1 and FAK work together to regulate the movement of Src away from focal adhesions and into the cell.

Ambra1 is recruited in a Parkin-dependent manner to perinuclear clusters of depolarized mitochondria, activates the class III phosphatidylinositol 3-kinase (PtdIns3K) complex around these mitochondria and contributes to their selective autophagic clearance.

3 天之前 · Among the genomic alterations identified as risk factors in mice models of autism spectrum disorders (ASD), heterozygous deletion of Ambra1 (Activating Molecule in Beclin1-Regulated Autophagy ...

In this review, we focus on AMBRA1, a proautophagic protein that was recently demonstrated to participate in numerous crucial regulative mechanisms of the autophagy process. Keywords: apoptosis, cancer, cell survival, embryonic development, mitophagy.