At age <30 years, 9.8% of females and 1.4% of males had elevated NT-proBNP, rising to 76.5% and 81.0%, respectively, at age ≥80 years. After adjusting for risk factors, an NT-proBNP ≥125 pg/mL was more common in females than males (OR, 9.48 [95% CI, 5.60–16.1]).

2023年5月5日 · Over recent years, greater clarity has been gained regarding the understanding of how to best interpret concentrations of B-type natriuretic peptide (BNP) or N-terminal (NT)-proBNP in ambulatory individuals with or without prior heart failure (HF).

2024年3月11日 · The natriuretic peptide system impacts salt and water handling and pressure regulation and may influence myocardial structure and function. B-type natriuretic peptide (BNP) is a natriuretic hormone initially identified in the brain but released primarily from the heart, particularly the ventricles.

For BNP, 100 pg/mL appears to be a consensus cutpoint. No clear consensus has emerged for NT-proBNP, but the age-adjusted cutpoints of 450 pg/mL for <50 years, 900 pg/mL for 50-75 years and 1,800 pg/mL for >75 years appear promising and merit greater scrutiny and validation.

age-adjusted cut-offs When NT-proBNP is used as a clinical tool for diagnosis of acute decompensated HF, age-adjusted cut-offs are often applied and this has been shown in several studies to be appropriate.

2024年10月28日 · The ESC Heart Failure Association (HFA) recently published a practical algorithm for early diagnosis of HF recommending age-specific rule-in NT-proBNP thresholds: ≥125pg/ml for patients aged under 50 years, ≥250pg/ml for patients aged 50-75 years, and ≥500pg/ml for patients over 75 years (Figure 1).2.

A B-type natriuretic peptide (BNP) test or aminoterminal pro B-type natriuretic peptide (NT-proBNP) test gives your provider essential information about your heart health. It helps them diagnose heart failure, so they can develop a treatment plan.

2023年4月23日 · Like BNP, NT-proBNP concentrations vary by age; the normal threshold for those under 50 years of age is 450 pg/mL, while it is 900 pg/mL for those greater than 50 years of age. The clinical importance of measuring one peptide …

In primary care, brain natriuretic peptide (BNP) is used for excluding heart failure. The Dutch and European Society of Cardiology heart failure guidelines apply two BNP cut-off levels without making distinction for gender and age.

2023年5月23日 · The reference values of brain-type natriuretic peptide (BNP) and N-terminal (NT) proBNP are different to exclude or confirm a diagnosis of heart failure. These values also depend on age and...