Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin -containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.

2024年12月24日 · ACACB (Acetyl-CoA Carboxylase Beta) is a Protein Coding gene. Diseases associated with ACACB include Bardet-Biedl Syndrome 18 and Leukoencephalopathy, Progressive, With Ovarian Failure. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism of steroids.

ACACB is a biomarker for CTX therapy in metastatic CRC. Cetuximab is one of the most valuable targeted therapy monoclonal antibodies in the treatment of metastatic colorectal cancer (CRC). However, the mechanisms affecting cetuximab resistance in CRC treatment remain unclear.

We sought to determine whether ACACB transcribed variants were associated with ACACB gene expression and insulin sensitivity in non-diabetic African American (AA) and European American (EA) adults.

Autophagy is differentially activated in B1a B cells, and deletion of the autophagy gene Atg7 leads to a selective loss of B1a B cells caused by a failure of self-renewal. Autophagy-deficient B1a B cells down-regulate critical metabolic genes and accumulate dysfunctional mitochondria.

2024年6月9日 · Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.

2025年1月4日 · Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.

2020年12月1日 · Altered lipid metabolism is a characteristic feature of cancer cells. This systematic review assesses the risk for cancer development in association with the expression levels of the ACACA and ACACB genes which encode the rate limiting enzymes of fatty acid synthesis, acetyl-CoA carboxylase α (ACCα) and acetyl-CoA carboxylase β (ACCβ).

2022年9月25日 · We find that acetyl-CoA carboxylase beta (ACACB), ADH1C, CES1, MGLL, FMO5, and GPT are the hub DEGs, and ACACB is the most important biomarker among them.

Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intractable drug target.