Human AP endonuclease (APE1), like most AP endonucleases, is of class II and requires an Mg 2+ in its active site in order to carry out its role in base excision repair. The yeast homolog of …

ape 1 切割 ap 位点 5´ 端的磷酸二酯键，产生单链 dna 断裂，留下 3´ 羟基和 5´ 脱氧核糖磷酸末端。

In this paper we review the research status of APE1 mediated functional nucleic acids biosensing techniques and other biosensing techniques for the detection of APE1, discuss the …

2022年9月14日 · Nature Communications - AP endonuclease 1 (APE1) processes genomic AP sites during base excision repair. Here, the authors determine the structural mechanism used …

APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has a pleiotropic role in …

2021年1月27日 · The exonuclease activity of Apurinic/apyrimidinic endonuclease 1 (APE1) is responsible for processing matched/mismatched terminus in various DNA repair pathways and …

2021年1月1日 · Mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1) has versatile enzymatic functions, including redox, endonuclease, and exonuclease activities. APE1 is thus …

Apurinic endonuclease 1 (APE1) is one of the key enzyme in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the 5'-end of an apurinic/apyrimidinic (AP) site to …

摘要： 脱嘌呤/脱嘧啶核酸内切酶1（Apurinic/apyrimidinic endonuclease 1,APE1）是一种广泛存在于生物体内、在碱基切除修复（Base excision repair,BER）过程中能够在碱基缺失位 …

2015年10月12日 · We report multiple high-resolution human APE1–DNA structures that divulge new features of the APE1 reaction, including the metal-binding site, the nucleophile and the …