Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it is a protein that is encoded by the RUNX1 gene, in humans.

AML1 encodes a nuclear transcription factor (TF) which shows homology in its 5' part with the Drosophila melanogaster segmentation gene, runt, and contains a transactivation domain in the carboxyterminal portion.

aml1-eto是在wnt/β这个东西诱导下使得8，21染色体易位形成的；又叫作runx1-runx1t1 形成的AML1-ETO长这样，相应片段可以和下面黑色mRNA或者蛋白质作用； 最常见的两种形式

2021年7月30日 · In this review, we will focus on recent results highlighting the role of AML1/ETO as an epigenetic modifier, which provides a strong rationale to treat the disease with so-called epigenetically...

2024年12月26日 · aml1–eto是急性髓性白血病（aml）中最常见的融合蛋白之一，由runx1::runx1t1融合基因编码，能够生成前白血病克隆。 2024年12月16日，中国医学科学院北京协和医院王敏，邱少伟和王建祥共同通讯在 Cancer Research 在线发表题为 “ Targeting Fatty Acid Metabolism Abrogates the ...

2024年12月25日 · Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. ( RUNX1_HUMAN,Q01196 ) Isoform AML-1L interferes with the transactivation activity of RUNX1.

AML1 antibody detects endogenous levels of total AML1 protein and the AML1/ETO fusion protein. Human, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala36 of human AML1 (RUNX1) protein. Antibodies are purified by protein A and peptide affinity chromatography.

2021年2月4日 · Transcription factors regulate gene networks controlling normal hematopoiesis and are frequently deregulated in acute myeloid leukemia (AML). Critical to our understanding of the mechanism of cellular transformation by oncogenic transcription factors is the ability to define their direct gene targets.

探讨伴AML1-ETO融合基因的急性髓系白血病（AML）患者ASXL2基因突变情况、突变阳性患者临床特征及ASXL2基因突变与c-kit基因突变的关系。 采用PCR扩增产物片段直接测序分析法，检测59例伴AML1-ETO融合基因初发AML患者ASXL2基因第11、12外显子编码区突变情况，比较ASXL2基因突变阳性和阴性组患者的临床特征、生存及c-kit基因突变情况。 59例患者中7例存在ASXL2突变，突变率为11.9%。

2011年12月15日 · Transcription factor AML1/RUNX1 is one of the most frequent targets of chromosomal abnormalities in human leukemia and altered function of AML1 is closely associated with malignant transformation of hematopoietic cells. However, the molecular basis and therapeutic targets of AML1-related leukemia are still elusive.