ADAR1: a mast regulator of aging and immunity - Nature
2023年1月4日 · On July 20, 2022, Nature published three papers on ADAR1 regulating abnormal immune activation through the canonical A-to-I RNA editing pathway. 1, 2, 3 The study by …
Targeting ADAR1 with a small molecule for the treatment of
2025年2月10日 · In this study, we demonstrate that highly expressed ADAR1 is a crucial oncogenic target in PCa and develop an effective small-molecule ADAR1 inhibitor, ZYS-1, with …
New insights into ADAR1 mechanisms could revolutionize …
2 天之前 · ADAR1 converts adenosine to inosine in double-stranded RNA, a process essential for preventing unwarranted immune responses, yet the molecular basis of this editing had …
The role of RNA editing enzyme ADAR1 in human disease
Recent studies show that editing-dependent functions of ADAR1 protect dsRNA from dsRNA-sensing molecules and inhibit innate immunity and the interferon-mediated response.
ADAR1: from basic mechanisms to inhibitors - Cell Press
2024年7月18日 · Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 …
ADAR1 RNA Editing: Key Discoveries & Disease Treatments
2 天之前 · ADAR1 converts adenosine to inosine in double-stranded RNA, a process essential for preventing unwarranted immune responses, yet the molecular basis of this editing had …
Biochemical profiling and structural basis of ADAR1-mediated …
3 天之前 · Deng et al. reveal mechanisms of ADAR1-mediated RNA editing through biochemical profiling and cryo-EM structure determination. They show how disease-related mutations …
Biochemical profiling and structural basis of ADAR1-mediated …
ADAR1 regulates RNA-induced immune responses by converting adenosine to inosine in double-stranded RNA. Mutations in ADAR1 are associated with human autoimmune disease, and …
Scientists gain insight into RNA-editing protein that could lead to ...
1 天前 · ADAR1's RNA editing mechanism. Researchers used biochemical and RNA sequencing analyses to explore how disease-associated mutations affect ADAR1's function, …
ADAR1 RNA editing enzyme regulates R-loop formation and genome ... - Nature
2021年3月12日 · ADAR1p110 edits the A-C mismatches within RNA:DNA hybrids formed between canonical and non-canonical variant repeats. Editing of A-C mismatches to I:C …
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