Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the ACTN3 gene (named sprinter gene, speed gene or athlete gene) located on chromosome 11. All …

2022年6月20日 · The ACTN3 gene controls fast-twitch muscle fibers, impacting power and endurance athletes. Check your genetic raw data.

ACTN3 is a gene that encodes for alpha-actinin-3, a protein expressed only in type-II muscle fibers (North et al., 1999). A common polymorphism in this gene is R577X (rs1815739), where a C-to-T base substitution results in the transformation of an arginine base (R) to a …

2024年12月24日 · ACTN3 (Actinin Alpha 3) is a Protein Coding gene. Diseases associated with ACTN3 include Actn3 Deficiency and Bruxism. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Striated muscle contraction pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and actin binding.

ACTN3 genotype frequency in controls, elite sprint/power athletes, and endurance athletes.

Several investigations have found that α-actinin-3 deficiency due to XX homozygosity in the ACTN3 R577X polymorphism can negatively affect sports performance through several structural, metabolic, or signaling changes.

2017年12月18日 · One of the most promising genes in that regard is ACTN3, which has commonly been referred to as "a gene for speed". Recent research has examined the influence of this gene on other performance phenotypes, including exercise adaptation, exercise recovery, and sporting injury risk.

2025年2月8日 · ACTN3 is one of many genes contributing to genetic variation in muscle performance and adaptation to exercise. Data report the crystal structure of the actin binding domain of human muscle alpha-actinin-3, which is formed by two consecutive calponin homology domains arranged in a "closed" conformation.

Here, we show that α-actinin-3 plays a key role in the regulation of protein synthesis and breakdown signaling in skeletal muscle and influences muscle mass from early postnatal development.

2023年12月20日 · Understanding the role of the actn3 gene can provide valuable information for athletes, coaches, and researchers working to optimize athletic training and performance. The Actn3 gene, also known as the alpha-actinin-3 gene, …