A-431 is a cell line exhibiting epithelial morphology that was isolated from the epidermis of an 85-year-old female patient with epidermoid carcinoma. This cell line is one of a series of cell lines established from solid tumors by D.J. Giard, et al. and can be used in cancer, toxicology, and immuno-oncology research.

ATCC number： CRL-1555™ 完全培养液配方：见下方备注 批次/冻存日期：详见 冻存管/培养瓶 标识 参考传代比例：1：3 参考传代周期：4-6天 参考换液频率：2-3天 冻存液配方：完全培养液95%，DMSO 5% 细胞状态：上皮样，贴壁生长 支原体检测结果：阴性 STR鉴定结果：

Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Population: Caucasian. Doubling time: ~80-100 hours (DSMZ=ACC-91). Karyotypic information: Hypertriploid karyotype (ATCC=CRL-1555). Microsatellite instability: Stable (MSS) (Sanger). Omics: Cell surface proteome. Omics: Deep antibody staining analysis.

a431细胞系来源于实体瘤，具有上皮形态，细胞呈贴壁生长，广泛应用于癌症生物学、免疫肿瘤学和毒理学研究领域，a-431细胞系常用于致瘤性研究。 A431细胞是超三倍体，模态染色体数为74，出现在约36%的细胞中，倍性较高的细胞比例为1.0%。

Excellent signal/background ratio and stable Luciferase expression make this cell line ideal for in vivo bioluminescence imaging of xenograft animal model to study human cancer and monitor activity of anti-cancer drug. It also can be used in cell-based assays for cancer research. Figure 1: In vivo detection of luciferase activity of A-431-Luc2.

a431 (亦稱atcc crl-1555) 是經常在生物醫學 研究中作為模型的人類 鱗狀細胞癌 細胞系 [1] ，a431細胞最初是從一個85歲女性鱗狀細胞癌患者中分離出來的。 A431細胞的 表皮生長因子 （EGF）刺激，可以誘導 細胞 內 信號蛋白 的 酪氨酸 快速 磷酸化 ，從而控制生長 ...

细胞描述:人表皮细胞癌细胞A-431 由D.J.Giard 等人建立,来源于一位85岁女性。 在免疫缺陷性小鼠皮下注射可成瘤,在琼脂上可形成克隆。 这是一个超三倍体人细胞株。 36% 的细胞染色体数目为74,1%的细胞具有更高的染色体倍数。 Faust JB, Meeker TC. Amplification and expression of the bcl-1 gene in human solid tumor cell lines. Cancer Res. 52: …

人皮肤鳞细胞A431源自一位患有皮肤鳞状细胞癌的85岁女性，是GiardDJ等人建立的一系列细胞株中的一株。 该细胞在免疫抑制小鼠体内可成瘤，在琼脂上培养可形成克隆；是一个超三倍体人细胞株。

A-431-Luc2 is an epithelial-like cell line that was isolated from the epidermis of an 85-year-old, female patient with epidermoid carcinoma. This cell line was deposited by ATCC and can be used in assay development and cancer research.

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