Adenosine A1 receptor - Wikipedia
The adenosine A 1 receptor (A1AR) [5] is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as endogenous ligand.
Central activation of the A1 adenosine receptor (A1AR) induces a ...
2013年9月4日 · Since central activation of A1 adenosine receptors (A1ARs) plays an important role in the induction of the hypothermic and hypometabolic torpid state in hibernating …
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黄文辉/Frank Kirchhoff团队Nat Commun:腺苷触发的早期星形胶质 …
2024年8月23日 · 采用小鼠败血症模型，作者发现腺苷作为一种免疫信号介质在血液和大脑中迅速增加并作用于星形胶质细胞腺苷A1 (A1 adenosine receptor, A1AR) 受体，促进星形胶质细胞 …
小药谈GPCR: GPCR的偏向配体 - 健康界
2021年3月1日 · AT1R是主要的血压调节受体，并且作为AT1R拮抗剂的血管紧张素受体阻滞剂（ARB）是广泛用于治疗高血压的药物。 通过对血管紧张素II（Ang II）的序列修饰，Trevena …
Structure of the adenosine-bound human adenosine A
2018年6月20日 · Here we report the 3.6 Å structure of the human A 1 R in complex with adenosine and heterotrimeric G i2 protein determined by Volta phase plate cryo-electron …
A1AR 激动剂和 A2AAR 拮抗剂联合治疗神经炎症,Molecules - X-MOL
2021年2月23日 · 结果表明 A1AR 激动剂能够在不同程度上 防止细胞因子混合物（肿瘤坏死因子（TNF）-α、 白细胞介素 (IL)-1β和干扰素 (IFN)-γ)，而A2AAR拮抗剂表现出良好的对抗能力 神 …
The human A1 adenosine receptor: ligand binding properties
The A1 adenosine receptor (A1AR) exerts important biological effects in the mammalian biology. To provide insights into the role A1AR action in human physiology, we characterized the …
The human A1 adenosine receptor: ligand binding properties ... - PubMed
The A1 adenosine receptor (A1AR) exerts important biological effects in the mammalian biology. To provide insights into the role A1AR action in human physiology, we characterized the …
A1腺苷受体激动剂，拮抗剂和变构调节剂的药物化学和治疗潜力： …
腺苷是嘌呤核苷，通过与四个g蛋白偶联受体（gpcr）结合，即a1，a2a，a2b和a3腺苷受体（ars），负责调节广泛的生理和病理生理状况。特别地，a1ar普遍存在，介导整个身体的各 …