4-Nitroquinoline N -oxide is a quinoline derivative widely used in chemical research and development. [1] 4-Nitroquinoline N -oxide has been used as a model compound to study its …

The 4NQO carcinogen model has the advantage that it can be used with transgenic mice with genetic modification in specific tissue types to investigate their role in driving cancer …

The 4NQO molecule forms DNA adducts, causes substitutions of adenosine for guanosine, and evokes intracellular oxidative stress, resulting in genetic mutations and DNA strand breaks.

4-Nitroquinoline-1-Oxide is a quinoline derivative with potent tumorigenic activity. 4-nitroquinoline-1-oxide (4-NQO) potentially induces DNA damage by either binding directly to DNA and …

4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4 …

2021年1月1日 · Many laboratories have used the chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) to investigate OSCC formation. The importance of the 4NQO mouse model is that it …

4-Nitroquinoline 1-oxide (4-NQO) is a highly carcinogenic chemical that induces mutations in bacteria, fungi, and animals through the formation of bulky purine adducts. 4-NQO has been …

Animal models that mimic histological and biological processes of human oral carcinogenesis may help to improve the identification of OPMD at-risk of progression into oral squamous cell …

Objective: Based on a critical review of published studies, we aimed to develop a good practice guide for using 4-nitroquinoline-1-oxide (4NQO) as an inducer of oral carcinogenesis in Wistar …

2022年8月1日 · 4-nitroquinoline-1-oxide (4NQO) is a mutagenic substance capable of generating changes in DNA that mimic tobacco-induced molecular events and can be used for …