2-Deoxy-D-glucose purchased from MCE. Usage Cited in: Ann N Y Acad Sci. 2023 Mar 18. 2-Deoxy-D-glucose (2-DG; 200 μM) reduces the protein levels of CASP11, cleaved-CASP11, NLRP3, GSDMD-FL, and GSDMD-NT, accompanied by effective inhibition of the markers involved in glycolysis, in OCCM-30 cells.

[6] [7] [8] Because of its structural similarity to mannose, 2DG has the potential to inhibit N-glycosylation in mammalian cells and other systems, and as such induces ER stress and the Unfolded Protein Response (UPR) pathway.

2-DG (2-Deoxy-D-glucose), 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。

2-deoxy-D-glucose (2DG) is a fake sugar that cancer cells eagerly absorb, preventing them from taking in real sugar and growing. This accumulation of 2DG slows down cancer cells, making them weaker and more vulnerable to treatments.

简介：2-Deoxy-D-glucose (2-脱氧-D-葡萄糖)是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase)来抑制糖酵解。2-Deoxy-D-glucose 具有抗病毒活性，还具有抑制细胞增殖、诱导细胞凋亡的活性。 别名：2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose 物理性状及指标：

Ahmad I. M., Mustafa E. H., Mustafa N. H., Tahtamouni L. H., Abdalla M. Y. 2DG enhances the susceptibility of breast cancer cells to doxorubicin. Central European Journal of Biology . 2010;5(6):739–748. doi: 10.2478/s11535-010-0060-y.

This leads to ATP depletion and the induction of cell-death[2]. 2DG significantly suppresses proliferation, causes apoptosis and reduces migration of murine endothelial cells, inhibiting formation of lamellipodia and filopodia and causing disorganization of F-actin filaments in murine endothelial cell[5].

2-Deoxy-D-glucose(2-脱氧-d-葡萄糖)是一种葡萄糖抗代谢物和 糖酵解抑制剂 ，它抑制己糖激酶（将葡萄糖转化为葡萄糖 6-磷酸的酶）和 磷酸葡萄糖异构酶 （将葡萄糖转化为 6-磷酸的酶）。 2-脱氧-D-葡萄糖 (16 mM) 在SK-BR-3细胞中诱导细胞凋亡，并在使用浓度为2时抑制在缺氧条件下培养的骨肉瘤细胞的生长。

2024年3月13日 · 在细胞代谢研究中，2-dg被广泛应用于探究细胞对葡萄糖的依赖程度以及葡萄糖代谢途径的调控机制。通过比较细胞在葡萄糖和2-dg存在下的代谢差异，科研人员可以深入了解细胞代谢的复杂性和多样性，为疾病的治疗提供新的思路。

2-脱氧-d-葡萄糖(2-deoxy-d-glucose)（以下称2dg）为白色粉状晶体，味臭，略甜，易溶于水，部分可溶于甲醇、乙醇、丙醇、丁醇。 不溶于氯仿、石油以及甲苯。