2-deoxy-D-glucose (2DG) is a fake sugar that cancer cells eagerly absorb, preventing them from taking in real sugar and growing. This accumulation of 2DG slows down cancer cells, making them weaker and more vulnerable to treatments.

2-Deoxy-d-glucose is a glucose molecule which has the 2- hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).

2-Deoxy-D-glucose (2-DG, 2-deoxy-D-arabino-hexopyranose) is a natural [1], nonmetabolizable glucose analog and a competitive inhibitor of glycolysis [2] in which the 2-hydroxyl group is replaced by hydrogen (Figure 1). 2-DG blocks the activity of different enzymes involved in glycolysis, leading to cell death.

2015年10月24日 · DeoxyGlucose (2DG) differs from normal glucose only by removal of an oxygen atom from the hydroxyl group at the 2 position. 2DG is one of the most relevant glycolysis inhibitor. Since it is a glycolysis inhibitor, it is relevant to all cancers visible on PET scan.

For optimal results, the recommended daily dosage of 2-Deoxy-Glucose (2DG) is 30 mg/kg (13.6 mg/lb) of body weight), split into two doses. Take 20 mg/kg in the morning after an overnight fast, and 10 mg/kg in the evening, at least three hours after your last meal.

2021年12月6日 · Here, we show that both compounds selected wild-type over mutant mtDNA, restoring mtDNA expression and respiration. Mechanistically, 2DG selectively inhibits the replication of mutant mtDNA; and...

2-Deoxy-D-glucose (2DG) is an analogue of glucose in which a 2-hydroxyl group is replaced by hydrogen. Despite this minor change in its structure, glucose transporters can still carry 2DG into cancer cells disguised as “fake sugar” that they crave intensely.

2014年12月28日 · Interfering with this process may be a potential effective strategy to cause cancer cell death because these cells rely heavily on glucose metabolism for survival and proliferation. 2-Deoxy-D-glucose (2DG), a glucose analog, targets glucose metabolism to deplete cancer cells of energy.

Our channel is dedicated to bringing you the latest information on 2-Deoxy-D-glucose (2DG), a substance being studied for its potential in cancer treatment. 2DG targets cancer cells by...

The ability of 2-deoxy- d -glucose (2-DG) to interfere with d -glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival.