The pre-BCR mediates signals resulting in heavy chain allelic exclusion, down-regulation of the recombination machinery, developmental progression, V(H) repertoire selection, proliferation …

The pre-BCR induces proliferative expansion of pre-B cells, which is missing in SL chain knockout mice. During the proliferative expansion, expression of the genes encoding SL chain is …

The first checkpoint in the development of a B cell is the production of a functional pre-BCR, which is composed of two surrogate light chains and two immunoglobulin heavy chains, which …

In this Review, we discuss how FOXO transcription factors are regulated by the pre-BCR to allow the progression of the cell cycle and the recombination of the light chain gene.

2018年11月14日 · The pre-BCR induces proliferative expansion of pre-B cells, which is missing in SL chain knockout mice. During the proliferative expansion, expression of the genes encoding …

The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig muH chain, surrogate light (SL) chains VpreB and lambda5, as well as the signal-transducing heterodimer …

At the pro-B to pre-B cell transition, the pre-B cell receptor (preBCR) checkpoint directs pre-B cell expansion and selection of the pre-B cell immunoglobulin (Ig) μ heavy chain variable region …

2013年7月25日 · Transformation of early B cells supplants the role of interleukin-7 receptor (IL-7R) and pre-B cell receptor (BCR) signalling. Continual BCR signalling is required for the …

The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis, differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central role in B cell …

2016年9月9日 · Precursor-B cell receptor (pre-BCR) signaling represents a crucial checkpoint at the pre-B cell stage. Aberrant pre-BCR signaling is considered as a key factor for B-cell …