2020年9月4日 · Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2.

2023年1月5日 · Here, we review recent advances that describe a role for mTORC2 in this catabolic process, and propose that mTORC2 could be a potential clinical target for the treatment of autophagy-related diseases.

In this review, we focus on recent developments on mammalian mTORC2 signaling mechanisms and its cellular and tissue-specific functions. Key words: mTOR, mTORC2, rictor, cancer, metabolism, ribosomes, protein synthesis, protein maturation, AGC kinases, growth factor signaling Introduction

mTORC2 is a negative regulator of macroautophagy and chaperone‐mediated autophagy via its ability to signal to various downstream effectors shown to modulate autophagy in mammals including AKT, PKC, SGK‐1, and FOXO transcription factors.

2023年10月2日 · The mTORC2 is a complex of mTOR, DEPTOR, mSIN1, Rictor, Protor, and mLST8 to regulate cell survival, proliferation, migration, and cytoskeleton remodeling. Created with BioRender.com

Hence, mTORC2 can promote mTORC1 signaling via Akt-mediated phosphorylation of TSC2 and other substrates involved in cell growth and metabolism, thus potentiating mTOR signaling (70, 74, 75). Additionally, mTORC2 enhances mTORC1 activation by repression of the class II …

2021年7月12日 · The mechanistic target of rapamycin (mTOR) has gathered significant attention as a ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation, and survival. This kinase forms the central core of two distinct complexes, mTORC1 and mTORC2, which share the ability of …

2009年4月21日 · The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid–induced protein kinase (SGK).

2024年7月10日 · In this review, we first summarized the basic characteristics of mTORC2, including its protein architecture and signaling network. We then focused on reviewing the molecular signaling regulation of mTORC2 in cellular senescence and organismal aging, and proposed the multifaceted regulatory characteristics under senescent and nonsenescent …

The growth-related functions of mTORC2 are conserved from yeast to humans and its stress-related function is critical to allow metabolic reprogramming and favor cell survival. In this review, we discuss the regulation and targets of mTORC2 and how it intersects with other cellular pathways to modulate responses to growth and stress stimuli.