2024年12月25日 · The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

2020年6月7日 · We show that transient ZSCAN4 induction for just 2 days increases CSC frequency both in vitro and in vivo and leads to upregulation of pluripotency and CSC factors.

2024年12月20日 · Zscan4 exhibits burst expression in 2C embryos and 2C-like cells. Here, we show that Zscan4 mediates chromatin remodeling to promote the chromatin accessibility for achieving the 2C-like state. Through coimmunoprecipitation/mass spectrometry, we identified that Zscan4 interacts with the corepressors Kap1/Trim28, Lsd1, and Hdac1, also with ...

2010年3月24日 · The transient Zscan4-positive state is associated with rapid telomere extension by telomere recombination and upregulation of meiosis-specific homologous recombination genes, which encode...

ZSCAN4能够调控早期胚胎发育过程,在合子基因组激活(zygotic genome activation, ZGA)期间通过促进DNA损伤修复和纠正染色体异常,以维持植入前胚胎的基因组和染色体完整性。

2020年3月20日 · One of the 2C-specific transcripts activated during the minor ZGA is Zscan4 (Zinc finger and SCAN domain–containing 4), encoded by a highly homologous six-gene cluster (Zscan4a-f) arising from recent duplications in mice .

2007年7月15日 · Utilizing DNA microarray data, we looked for genes that are expressed only during ZGA and found Zscan4, whose expression is restricted to late 2-cell stage embryos. Sequence analysis of genomic DNA and cDNA clones revealed nine paralogous genes tightly clustered in 0.85 Mb on mouse chromosome 7.

2025年2月8日 · The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

2007年7月15日 · Zscan4 is the first example of a gene that is expressed exclusively in late 2-cell embryos and embryonic stem (ES) cells. Loss-of-function study by siRNA technology indicates the important function of Zscan4 genes for the progression from 2- to 4-cell stages and subsequent embryo development.

2016年4月12日 · If Zscan4 is activated for repair by sensing shortened telomeres, the upregulation of Zscan4 should be followed by shortening of the cell cycle after the recovery of the telomere. Thus we analyzed the correlation between the Zscan4 promoter activity and the change in the cell-cycle length in the next generation.