2024年12月25日 · ZEB2 (Zinc Finger E-Box Binding Homeobox 2) is a Protein Coding gene. Diseases associated with ZEB2 include Mowat-Wilson Syndrome and Large Congenital Melanocytic Nevus. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function.

2024年1月25日 · Dai et al. report that the transcription factor ZEB2 is critical in driving ABC formation and pathogenicity in both mice and humans. ZEB2 promotes the gene signature, phenotype (e.g., CD11c expression), and function (e.g., phagocytic ability) of ABCs.

ZEB2, originally named SIP1 (and ZFHX1B), was discovered in a yeast 2-hybrid screening together with other candidate SMAD-interacting proteins (SIPs) from mid-gestation mouse embryos, using the transcription activation (i.e., MH2) domain of BMP-SMAD1 as bait [1].

The ZEB2 gene provides instructions for making a protein that plays a critical role in the formation of many organs and tissues before birth. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.

2023年10月30日 · Zeb2 is a zinc finger E homeobox-binding transcription factor and is expressed in a variety of immune cells, but its function in iNKT cell differentiation remains also unknown. Here, we show that...

2024年1月26日 · In mice with toll-like receptor 7 (TLR7)-driven lupus, ZEB2 is essential for ABC formation and autoimmune pathology. ZEB2 binds to +20-kb myocyte enhancer factor 2b (Mef2b)'s intronic enhancer, repressing MEF2B-mediated germinal center B cell differentiation and promoting ABC formation.

2022年2月8日 · Zeb2 regulates SMC phenotypic transition through chromatin remodeling that obviates accessibility and disrupts both Notch and transforming growth factor β signaling, thus altering the epigenetic trajectory of SMC transitions.

Zinc finger E-box binding homeobox (Zeb) 2 is a transcription factor, identified due its ability to bind Smad proteins, and consists of multiple functional domains which interact with a variety of transcriptional co-effectors.

2015年9月1日 · Zeb2 regulates CNS and PNS induction and development. The effect of the knockdown of Zeb2 on nervous system development described. Molecular and cellular mechanisms of Zeb2-regulation of neurogenic and gliogenic …

2022年1月6日 · From human genetics, we discovered that ZEB2, a master regulator of epithelial to mesenchymal transition associated with many cancers, is a coronary artery disease–associated gene. Lower Zeb2 in smooth muscle cell results in plaques with high-risk features.