XPO1 - Wikipedia
Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.
XPO1 Gene - GeneCards | XPO1 Protein | XPO1 Antibody
2024年12月25日 · XPO1 (Exportin 1) is a Protein Coding gene. Diseases associated with XPO1 include Leukemia, Chronic Lymphocytic and Primary Mediastinal Large B-Cell Lymphoma. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Transport of the SLBP independent Mature mRNA.
The nuclear export protein XPO1 — from biology to targeted …
2020年11月10日 · The nuclear export protein exportin 1 (XPO1) is crucial for the maintenance of cellular homeostasis as it mediates the transport of >200 proteins, many of which are tumour suppressors, from...
The nuclear export protein XPO1 provides a peptide ligand for …
2024年8月23日 · XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules that target XPO1 are being used in ...
Targeting XPO1 enhances innate immune response and inhibits
2021年1月4日 · These results illustrate a novel mechanism by which XPO1 mediates innate immune response and KSHV replication, and identify XPO1 as a potential therapeutic target and KPT-8602 as a promising ...
XPO1-dependency of DEK::NUP214 leukemia | Leukemia - Nature
2 天之前 · The nuclear export protein XPO1 interacts with nucleoporin 214 (NUP214) and has been implicated in the pathogenesis of SET::NUP214 acute myeloid leukemia (AML). We evaluated DEK::NUP214 (DN ...
XPO1 Enables Adaptive Regulation of mRNA Export Required for …
XPO1 regulates the dynamic ribonucleoprotein nuclear export in response to genotoxic stress to support tolerance and can be targeted to enhance the sensitivity of cancer cells to endogenous and exogenous DNA damage.
A method for quantification of exportin-1 (XPO1) occupancy by …
Selective Inhibitor of Nuclear Export (SINE) compounds are a family of small-molecules that inhibit nuclear export through covalent binding to cysteine 528 (Cys528) in the cargo-binding pocket of Exportin 1 (XPO1/CRM1) and promote cancer cell death. ...
7514 - Gene ResultXPO1 exportin 1 [ (human)] - National Center …
HMGB2-induced calreticulin translocation required for immunogenic cell death and ferroptosis of cancer cells are controlled by the nuclear exporter XPO1. Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in …
The molecular mechanism and challenge of targeting XPO1 in …
XPO1 preferentially exports ribosomal RNA (60S and 40S subunits), regulating ribosomal biogenesis. In addition, XPO1 is responsible for selectively transporting certain subsets of mRNAs, miRNA, and snRNA through exporting several RNA-binding proteins and adaptor proteins [119,120].