X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. [5][6] The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. [7]

2024年12月25日 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related pathways are Unfolded Protein Response (UPR) and Cellular responses to stimuli.

2020年8月8日 · 下面我们来说说三条通路具体怎么激活。 1. IRE1α-xbp1通路： IRE1α首先发生磷酸化，并形成二聚体。 p-IRE1α接下来会催化一个重要的过程：使Xbp1 mRNA发生剪切，形成一个功能活跃的转录因子Xbp1s。

As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease progression and prognosis.

The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) stress, unspliced Xbp1 mRNA is cleaved by the activated stress ...

2022年11月11日 · 该研究发现，肿瘤细胞内IRE1α/XBP1信号通路的活化通过促进自身胆固醇的合成和分泌，抑制抗肿瘤免疫，促进了肿瘤生长。 研究人员首先通过比较TCGA和GTEx数据库中肿瘤组织和正常组织中XBP1 mRNA表达水平，发现肿瘤组织中XBP1高表达。

剪接的 mRNA 中 26 nt 的损失会导致移码和亚型 XBP1 (S) ，这是功能活跃的转录因子。 由未剪接的 mRNA XBP1 (U) 编码的亚型组成型表达，并被认为作为 XBP1 (S) 的负反馈调节剂起作用，它在 ER 应激的恢复阶段关闭靶基因的转录。

2023年2月17日 · XBP1 deficiency reduced tissue damage and cell apoptosis, protecting the mitochondria. Disruption of XBP1 was associated with reduced NLRP3 and cleaved caspase-1 levels and markedly improved...

XBP-1s binds to and activates the KSHV immediate-early gene ORF50. Overexpression of spliced XBP1 prevents cell cycle arrest and antiestrogen-induced cell death through the mitochondrial apoptotic pathway. XBP1 and the unfolded protein response modulate responsiveness to estrogens and antiestrogens in breast cancer.

2016年10月18日 · The isoform encoded by the unspliced mRNA, XBP1 (U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1 (S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]