The VKORC1 protein is a key enzyme in the vitamin K cycle. VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is …

The VKORC1 gene encodes the VKORC1 (vitamin K epoxide reductase) protein, which is a key enzyme in the vitamin K cycle [1, 2]. VKORC1 is a 163 amino acid integral membrane protein …

The VKORC1 gene provides instructions for making a vitamin K epoxide reductase enzyme. The VKORC1 enzyme is made primarily in the liver. It spans the membrane of a cellular structure …

2012年3月8日 · Warfarin targets VKORC1, an enzyme involved in vitamin K recycling. A common variant, , c.-1639G>A, is associated with an increased sensitivity to warfarin and lower dose …

2024年12月25日 · VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1) is a Protein Coding gene. Diseases associated with VKORC1 include Vitamin K-Dependent Clotting …

Genetic studies have shown that the VKORC1 gene extends over 5126 base pairs on human chromosome 16 and comprises three exons. Mutations in the VKORC1 gene causes …

Polymorphisms in the vitamin K-epoxide reductase complex subunit 1 gene, Vkorc1, could affect blood coagulation and other vitamin K-dependent proteins, such as osteocalcin (bone Gla …

2024年9月18日 · Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes.

2025年2月8日 · Overexpression of VKORC1 can be utilized for increased cellular production of recombinant vitamin K-dependent proteins. Genetic variants of the VKORC1 gene locus …

2021年12月17日 · The VKORC1 gene encodes vitamin K epoxide reductase complex subunit-1, a small transmembrane protein of the endoplasmic reticulum, which plays a major role in the …