2024年12月25日 · UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Diseases associated with UNC5B include Hyperinsulinemic Hypoglycemia, Familial, 3 and Epilepsy. …

2022年3月4日 · Blood-brain barrier (BBB) integrity is critical for proper function of the central nervous system (CNS). Here, we show that the endothelial Unc5B receptor controls BBB …

2021年8月11日 · We show that UNC5B-Δ8 is a constitutively pro-apoptotic splicing isoform insensitive to Netrin-1 and required for specific blood vessel development in an apoptosis …

2025年1月4日 · UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53. Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in …

We demonstrate that the intracellular domain of UNC5B promotes cell proliferation in vitro and tumour formation in vivo, by binding to a large number of ribosomal proteins. The …

2004年10月27日 · We show here that the repulsive netrin receptor UNC5B is expressed by endothelial tip cells of the vascular system. Disruption of the Unc5b gene in mice, or of Unc5b …

UNC5B is a single pass transmembrane receptor protein composed of an extracellular region, a transmembrane region, and a cytoplasmic region. Extracellular region embraces two …

2022年3月4日 · Inducible endothelial-specific deletion of Unc5B in adult mice leads to BBB leak from brain capillaries that convert to a barrier-incompetent state with reduced Claudin-5 and …

2009年3月27日 · To provide a foundation for the elucidation of the UNC5-mediated signaling mechanism, we determined the crystal structure of the cytoplasmic portion of UNC5b. We …

2024年12月10日 · Title: UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53. Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in …