TRPM channels in health and disease - Nature Reviews Nephrology
2023年10月18日 · Melastatin-like transient receptor potential (TRPM) channels are multifunctional cation channels with diverse biophysical and physiological characteristics. Eight family …
TRP (transient receptor potential) ion channel family: structures ...
2023年7月5日 · Transient receptor potential (TRP) channels, which were first discovered in 1969, 1 they are multimodal ion channels that act as sensors of chemically toxic and physical...
TRPM channels in health and disease - PubMed
TRPM channels are abundantly expressed in the kidney. Mutations in TRPM genes cause several inherited human diseases, and preclinical studies in animal models of human disease have …
TRPM Channels in Human Diseases - PubMed
2020年12月4日 · The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress …
A structural overview of the ion channels of the TRPM family
2020年1月1日 · The TRPM (transient receptor potential melastatin) family belongs to the superfamily of TRP cation channels. The TRPM subfamily is composed of eight members that …
Evaluation of the TRPM protein family as potential biomarkers …
The Transient Receptor Potential Melastatin (TRPM) protein family members have been demonstrated to be involved in a variety of different types of human cancer. However, to the …
Melastatin-like transient receptor potential (TRPM) channels are multifunctional cation channels with diverse biophysical and physiological characteristics. Eight family members have been...
Targeting TRPM channels for cerebral ischemia–reperfusion injury
2024年7月16日 · Transient receptor potential melastatin (TRPM) channels have emerged as potential therapeutic targets for cerebral ischemia–reperfusion (I/R) injury. We highlight recent …
Structural mechanisms of TRPM7 activation and inhibition
We identify a binding site for highly potent and selective inhibitors and show that they act by stabilizing the TRPM7 closed state. The discovered structural mechanisms provide …
TRPM3, TRPM4, and TRPM5 as thermo-sensitive channels
2024年9月18日 · Most transient receptor potential (TRP) channels are non-selective cation channels. In mammals, TRP channels are divided into six subfamilies: TRPC (canonical), …
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