TACSTD2 - Wikipedia
Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) [5] is a protein that in humans is encoded by the TACSTD2 …
Overview of Trop-2 in Cancer: From Pre-Clinical Studies to Future ...
2023年3月13日 · In our work, we briefly summarize the various characteristics of cancer cells overexpressing Trop-2, the pre-clinical activities of specific inhibitors, and the role of anti-Trop …
Trop-2 Antibody-Drug Conjugates for Metastatic Breast Cancer
2025年3月3日 · What are Trop-2 antibody-drug conjugates? Most breast cancers have cells that express the protein Trop-2. Trop-2 antibody-drug conjugate drugs combine a Trop-2 antibody …
TROP2--肿瘤治疗的新靶点 - 知乎 - 知乎专栏
TROP2 全称为人滋养细胞表面糖蛋白抗原2，是由染色体1P32区域的 Tacstd2基因 编码表达的细胞表面糖蛋白，与上皮黏附分子 Epcam 有较高的结构序列相似性，同源性达49%。 TROP2 …
TROP2 ADC: Promising Breakthrough in Cancer Therapy
2025年2月8日 · TROP2, or trophoblast cell surface antigen 2, is significant in cancer biology due to its overexpression in various epithelial cancers. This transmembrane glycoprotein, encoded …
The Rise of the TROP2-Directed ADCs for Solid Tumors
2022年3月2日 · On April 23, 2020, Trodelvy (Sacituzumab govitecan), the first ADC drug targeting Trop-2, received accelerated approval from the FDA for the treatment of unresectable locally …
Trop-2 Directed Antibody-Drug Conjugates for the Treatment of …
2022年2月25日 · This article provides an overview of antibody-drug conjugates for the treatment of solid tumors and examines emerging evidence demonstrating Trop-2 as a potential target in …
The emergence of trophoblast cell-surface antigen 2 (TROP-2) as …
2018年6月22日 · TROP-2 is a glycoprotein first described as a surface marker of trophoblast cells, but subsequently shown to be increased in many solid cancers, with lower expression in …
Progress and Innovative Combination Therapies in Trop-2 …
2024年5月17日 · Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely in normal tissues, rendering it an attractive target. Trop-2-targeted antibody …
Noninvasive molecular imaging using anti-Trop-2 aptamer for …
2025年3月6日 · Recent advancements in antibody-drug conjugates (ADCs) targeting trophoblast surface cell antigen 2 (Trop-2) have brought important progress in the field of targeted therapy. …